৳ 200/unit
Pack: ৳ 2,000
৳ 200/unit
Pack: ৳ 2,000
At a glance
Valbenazine Tosylate is indicated for the treatment of adults with Tardive Dyskinesia.
Indications
- Tardive Dyskinesia
Pharmacology
Valbenazine and its active metabolites bind to and inhibit VMAT2 with high selectivity with no significant binding to VMAT1. This prevents the reuptake and storage of monoamine neurotransmitters noradrenaline, dopamine, and serotonin in synaptic vesicles.
Dosage
Adult Dose (Oral):
- Initial dose: 40 mg once daily
- After one week: increase to 80 mg once daily
- Continuation of 40 mg once daily may be considered for some patients
- Administer with or without food
Side effects
Common Side Effects:
- Somnolence
- QT Prolongation
Use in pregnancy
Use in Pregnancy: Limited available data; insufficient to inform a drug-associated risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Can cause somnolence; may impair ability to drive or operate hazardous machinery
- May prolong QT interval; avoid in patients with congenital long QT syndrome or arrhythmias associated with prolonged QT interval
- Dose reduction may be necessary for CYP2D6-poor metabolizers or patients taking strong CYP2D6 inhibitors
- No dosage adjustment for mild to moderate renal impairment; not recommended in severe renal impairment
Overdose effects
Symptoms: No information from clinical trials regarding overdose symptoms.
Treatment: No specific antidotes; provide supportive care, close medical supervision and monitoring.
Storage conditions
Store below 25°C, in a cool & dry place. Keep away from light. Keep all medicines out of reach of children.