৳ 1,568/unit
Pack: ৳ 1,568
৳ 1,568/unit
Pack: ৳ 1,568
At a glance
Teicoplanin is a glycopeptide antibiotic used for the treatment of serious Gram-positive bacterial infections in hospitalized patients. It kills bacteria by inhibiting cell wall synthesis.
Indications
- Complicated skin and soft tissue infections
- Bone and joint infections
- Hospital-acquired pneumonia
- Community-acquired pneumonia
- Complicated urinary tract infections
- Infective endocarditis
- Clostridium difficile infection-associated diarrhea and colitis
Pharmacology
Teicoplanin binds to D-alanyl-D-alanine residues in the bacterial cell wall, inhibiting peptidoglycan synthesis. It is effective against Gram-positive bacteria and is more active than vancomycin against enterococci and some anaerobes.
Dosage
Adult Dose (Parenteral):
- General infections: 6 mg/kg on day 1; then 3 mg/kg/day
- Severe infections: 6 mg/kg every 12 hours (first 3 doses); then 6 mg/kg/day
- CAPD-associated peritonitis: 400 mg loading; add 20 mg/liter to dialysis fluid
Pediatric Dose (Parenteral):
- Loading: 10 mg/kg every 12 hours (3 doses); then 6-10 mg/kg/day
- Neonates: 16 mg/kg on day 1; then 8 mg/kg/day
Side effects
Common Side Effects:
- Injection site reactions (pain, swelling, redness)
- Fever, itching, skin rash
- Nausea, vomiting, diarrhea
- Dizziness, headache
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Cross-hypersensitivity may occur in patients hypersensitive to vancomycin
- Caution with nephrotoxic or ototoxic drugs
- Dose adjustment required in severe renal impairment
- Caution in pregnancy and lactation
Overdose effects
No overdose information; excessive doses may cause nephrotoxicity or ototoxicity; provide symptomatic treatment.
Storage conditions
Store below 30°C in a dry place, protected from light; reconstituted solution can be stored at 2-8°C for up to 24 hours.