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At a glance

Trifluoperazine is a prescription medicine used in the treatment of schizophrenia. It alters thoughts and elevates mood, improving the person's ability to think, feel and behave.

Indications
  • Anxiety disorder
  • Schizophrenia
  • Psychotic disorders
  • Nausea and vomiting
Pharmacology

Trifluoperazine is one of the phenothiazine class of compounds. Its most notable action is antagonism at dopamine receptors in the CNS. This action in the limbic system and associated areas of cerebral cortex is the basis of its antipsychotic action, whilst in the medullary chemoreceptor trigger zone it appears to be responsible for the antiemetic effect.

Dosage

Adult Dose (Oral):

  • Psychoses/Schizophrenia: Outpatient 1-2 mg every 12 hours; Inpatient initial 2-5 mg every 12 hours; maintenance 15-20 mg/day; not to exceed 40 mg/day
  • Anxiety: 1-2 mg twice daily; max 6 mg daily; max duration 12 weeks

Child Dose: 6-12 years: 1 mg once or twice daily; not to exceed 15 mg/day; >12 years: 2-5 mg every 12 hours

Side effects

Common Side Effects:

  • Orthostatic hypotension
  • Sleepiness
  • Dry mouth
  • Abnormality of voluntary movements
  • Weight gain
  • Increased prolactin level in blood
  • Urinary retention
  • Constipation
  • Muscle stiffness
  • Tremor
Use in pregnancy

Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect ability to drive
  • May cause dizziness, drowsiness or blurred vision
  • Rise slowly if you have been sitting or lying down
  • Avoid alcohol
  • Inform doctor if abnormal movements of face, lips, jaw and tongue occur
  • May increase blood sugar and cholesterol; monitor regularly
  • Do not stop suddenly
Overdose effects

Symptoms: Extrapyramidal symptoms, hypotension.

Treatment: Gastric lavage, supportive; anticholinergic/antiparkinsonism drug; fluid replacement.

Storage conditions

Store at room temperature between 15-30°C away from light and moisture.

Trifluoperazine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.