Telmicon-M 5/4040mg+5mg

Used for the treatment of hypertension (high blood pressure). Can be used alone or with other antihypertensive medicines. Effective for patients who do not achieve blood pressure control with a single medicine.

Adult Dose: May increase frequency and/or severity of angina during treatment initiation or dosage increments. Heart failure or hepatic impairment. Avoid fetal or neonatal exposure Hypotension: Correct any volume or salt depletion before initiating therapy. Observe for signs and symptoms of hypotension. Titrate slowly in patients with hepatic or severe renal impairment Heart failure: Monitor for worsening Avoid concomitant use of an ACE inhibitor and angiotensin receptor blocker Myocardial infarction: Uncommonly, initiating a CCB in patients with severe obstructive coronary artery disease may precipitate myocardial infarction or increased angina Lactation: Discontinue drug or do not breast feed Child Dose: Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters) Renal Dose: Telmisartan, a non-peptide angiotensin receptor blocker (ARB), is specific angiotensin II antagonist acting on the AT1 subtype. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium, which leads to an increase in blood pressure (hypertension). Telmisartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Therefore, Telmisartan dilates blood vessels and reduces blood pressure without affecting pulse rate. Telmisartan has much greater affinity (>3,000 fold) for the AT1 receptor than for the AT2 receptor. It does not bind or block other hormone receptors or ion channels known to be important in cardiovascular regulation. Amlodipine, a dihydropyridine calcium-channel blocker (CCB), inhibits the transmembrane influx of calcium ion into vascular smooth muscle and cardiac muscle. Amlodipine is a peripheral arterial vasodilator that acts directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and reduction in blood pressure.

Common: • Sleepiness • Ankle swelling • Headache • Flushing (sense of warmth in the face, ears, neck and trunk) • Dizziness • Tiredness • Palpitations • Upset stomach • Increased potassium level in blood

[UNSAFE] Telmisartan + Amlodipine may cause side effects which could affect your ability to drive. It may cause dizziness, headaches, nausea or tiredness, all of which could affect your ability to concentrate and drive. Telmisartan + Amlodipine is a combination of two medicines that provides better blood pressure control than either medicine alone. Telmisartan + Amlodipine may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause you to feel lightheaded or weak especially when you stand up. Rise slowly if you have been sitting or lying down. Avoid consuming alcohol as it may enhance the blood pressure lowering effect of this medicine. It can cause ankle or foot swelling. Raise your legs while you are sitting down and talk to your doctor if it does not go away. Do not take Telmisartan + Amlodipine if you are pregnant, planning to conceive or breastfeeding.