৳ 600/unit
Pack: ৳ 600
৳ 600/unit
Pack: ৳ 600
At a glance
Temozolomide Hydrochloride is an anti-cancer drug used for glioblastoma multiforme, anaplastic astrocytoma, and metastatic melanoma. It inhibits cell division by alkylating DNA in cancer cells.
Indications
- Glioblastoma multiforme (adults) – with focal radiotherapy
- Anaplastic astrocytoma (recurrent or progressive)
- Metastatic melanoma
Pharmacology
Temozolomide is an inactive prodrug that hydrolyzes at physiological pH to the active metabolite MTIC. MTIC alkylates DNA at O6 and N7 positions of guanine, causing DNA cross-linking and strand breaks, which arrests the cell cycle and induces apoptosis in cancer cells.
Dosage
Adult Dose (Oral):
- Glioblastoma (concomitant): 75 mg/m²/day (42 days) + radiotherapy
- Glioblastoma (adjuvant): 150-200 mg/m²/day (5 days) – 23 days break (6 cycles)
- Recurrent/progressive glioma (chemotherapy-naive): 200 mg/m²/day (5 days) – 23 days break
- Recurrent/progressive glioma (prior chemo): 150 mg/m²/day (5 days) – 23 days break; increase to 200 mg/m² for cycle 2
- Metastatic melanoma: 200 mg/m²/day (5 days) – every 28 days
Side effects
Common Side Effects:
- Nausea, vomiting, constipation
- Headache, fatigue, weakness
- Diarrhea, dizziness, fever
- Hair loss, loss of appetite, insomnia
- Rash, viral infection
Serious:
- Myelosuppression (neutropenia, thrombocytopenia)
- Opportunistic infections (PCP)
- Secondary leukemia
Use in pregnancy
Use in Pregnancy: Highly unsafe (Category D); evidence of fetal risk; use only in life-threatening situations; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Highly unsafe in pregnancy (Category D)
- Do not use in severe myelosuppression
- Risk of infection; avoid contact with sick individuals
- Regular blood tests (CBC, liver, kidney function) required
- Both males and females should use effective contraception (during treatment and 6 months after)
Overdose effects
Overdose may cause myelosuppression; no specific antidote; provide supportive care; hemodialysis is not effective.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.