Tendonil 60

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) and a glycolic acid ester of indomethacin used to treat pain, swelling, and inflammation associated with joint and muscle disorders.

Indicated for pain and inflammation in musculoskeletal and joint disorders such as rheumatoid arthritis, osteoarthritis, low back pain, and post-operative pain.

Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indole Acetic Acid Derivative

Acemetacin acts as a prodrug converted to indomethacin in the body. It inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis responsible for pain and inflammation.

Reversible inhibition of cyclooxygenase enzymes (COX-1 and COX-2) leading to decreased synthesis of inflammatory prostaglandins.

Recommended starting dose is 120 mg/day in divided doses, increasing up to 180 mg/day in divided doses depending on clinical response.

Must be taken with food, milk, or an antacid to minimize gastrointestinal disturbance.

Take as soon as remembered unless it is almost time for the next scheduled dose. Never double the dose.

Common: Anorexia, nausea, vomiting, diarrhea, constipation, peptic ulceration, headache, dizziness, vertigo. Rare: Confusion, depression, edema, chest pain, elevated blood urea.

Use with caution in elderly patients, those with a history of GI disorders, IBD, kidney disease, liver disease, or heart failure.

Contraindicated in patients with known hypersensitivity to acemetacin or indomethacin, active peptic ulceration, and in children.

Reduces antihypertensive effect of beta-blockers. Increases risk of convulsions with quinolones. Increased GI bleeding risk with aspirin, NSAIDs, or corticosteroids. Increases methotrexate toxicity.

Taking with food reduces GI irritation. Avoid alcohol as it increases GI ulceration risk.

Pregnancy Category C (Category D in 3rd trimester). Not recommended during pregnancy as safety is not established.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Excretion in human milk is possible; therefore, use during lactation is not recommended.

Safety and effectiveness in children have not been established.

Dose adjustment is not normally required, but elderly patients are more prone to adverse reactions.

Use with extreme caution in patients with renal or hepatic impairment.

Overdose may cause severe headache, nausea, abdominal pain, or GI bleeding. Symptomatic and supportive treatment is required.

Store below 25°C in a cool, dry place away from light. Keep out of reach of children.

Acemetacin (C21H18ClNO6)

Question: Should Acemetacin be taken with food? Answer: Yes, it must be taken with food, milk, or an antacid to reduce stomach upset. Question: Can it be given to children? Answer: No, the safety and efficacy of Acemetacin in children have not been established.