osudhkosh
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Company•Leeford Healthcare Ltd

Texifen 250

Rx
Generic: Terbinafine

৳ 42.86/unit

Pack: ৳ 300.02

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At a glance

Terbinafine is an allylamine antifungal used for skin and nail fungal infections. It kills fungi by inhibiting squalene epoxidase, preventing ergosterol synthesis.

Indications
  • Onychomycosis (nail fungal infections)
  • Tinea capitis
  • Tinea pedis (athlete's foot), tinea corporis, tinea cruris
  • Cutaneous candidiasis, pityriasis versicolor
Pharmacology

Terbinafine inhibits squalene epoxidase, preventing ergosterol synthesis, causing accumulation of squalene and increased membrane permeability. It exhibits fungicidal activity against dermatophytes and some yeasts.

Dosage

Adult Dose (Oral):

  • Fingernail: 250 mg/day for 6 weeks
  • Toenail: 250 mg/day for 12 weeks

Pediatric Dose (Granules, Tinea Capitis):

  • <25 kg: 125 mg/day for 6 weeks
  • 25-35 kg: 187.5 mg/day for 6 weeks
  • >35 kg: 250 mg/day for 6 weeks

Topical (Cream/Spray):

  • Tinea corporis/cruris: 1-2 times daily (1-2 weeks)
  • Tinea pedis: 1-2 times daily (1 week)
  • Candidiasis/pityriasis versicolor: 1-2 times daily (2 weeks)
Side effects

Common Side Effects:

  • GI symptoms (diarrhea, dyspepsia, abdominal pain)
  • Elevated liver enzymes, rash, urticaria, pruritus
  • Taste disturbances
  • Topical: Application site burning, itching

Serious (Rare):

  • Liver failure, severe skin reactions (SJS, TEN)
  • Neutropenia, thrombocytopenia
  • Angioedema, anaphylaxis
Use in pregnancy

Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in chronic or active liver disease (oral)
  • Perform liver function tests (ALT, AST) before treatment
  • Do not use in renal impairment (CrCl <50)
  • Caution in pregnancy and lactation
Overdose effects

Overdose (up to 5 g) may cause nausea, abdominal pain, dizziness, rash, frequent urination; provide symptomatic treatment.

Storage conditions

Store below 30°C in a cool and dry place, protected from light; keep out of reach of children.

Terbinafine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.