Thiocil 50
Rx- Generic:
- Propylthiouracil
- Company:
- Incepta Pharmaceuticals Ltd.
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
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৳ 10/unit
Pack: ৳ 100
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At a glance
Propylthiouracil is an anti-thyroid medication used for hyperthyroidism, particularly in patients with Graves' disease or toxic multinodular goiter who are intolerant of methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option.
Indications
- Graves' disease with hyperthyroidism or toxic multinodular goiter (methimazole-intolerant)
- Amelioration of hyperthyroidism symptoms in preparation for thyroidectomy or radioactive iodine therapy (methimazole-intolerant)
Dosage
Adult Dose (Oral):
- Hyperthyroidism: 150-450 mg daily in divided doses; severe cases: 600-1200 mg daily initially; maintenance: 50-150 mg daily
- Hepatic impairment: Dose reduction recommended
- Treatment usually continued for 1-2 years
Pediatric Dose (Oral):
- Neonates: 2.5-5 mg/kg twice daily
- 1 month-1 year: 2.5 mg/kg three times daily
- 1-5 years: 25 mg three times daily
- 5-12 years: 50 mg three times daily
- 12-18 years: 100 mg three times daily
Side effects
Side Effects:
- Skin rash
- Urticaria
- Pruritus
- Abnormal hair loss
- Skin pigmentation
- Nausea, vomiting
- Arthralgia
- Myalgia
- Paresthesia
- Headache
- Leukopenia
- Agranulocytosis
- Hepatitis, hepatic failure
Precautions & warnings
- Risk of agranulocytosis; report sore throat, fever, mouth ulcers, malaise immediately
- Severe hepatic reactions (fatal) may occur; occurs within first 6 months; discontinue if liver enzyme abnormalities develop
- Monitor prothrombin time before surgery
- Use lowest possible dose during pregnancy
- Monitor neonatal development during lactation
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.