Tiapine 25

• Schizophrenia (acute and chronic psychoses)
• Bipolar disorder (manic episodes)
• Bipolar disorder (depressive episodes)
• Maintenance treatment of bipolar I disorder
• Major depressive disorder (adjunctive therapy)

Adult Dose (Oral):

• Schizophrenia (IR): Day 1: 50 mg/day; Days 2-3: increase by 25-50 mg; Day 4: 300-400 mg; maintenance 150-750 mg/day
• Schizophrenia (XR): Day 1: 300 mg/day; Day 2+: increase by 300 mg/day; maintenance 400-800 mg/day
• Bipolar mania (IR): Day 1: 100 mg/day; Day 2: 200; Day 3: 300; Day 4: 400; Day 6: up to 800 mg/day; maintenance 400-800 mg/day
• Bipolar mania (XR): Day 1: 300 mg/day; Day 2: 600 mg/day; maintenance 400-800 mg/day
• Bipolar depression: Day 1: 50 mg at bedtime; Day 2: 100; Day 3: 200; Day 4: 300 mg at bedtime (maintenance)
• MDD (adjunct): Days 1-2: 50 mg in evening; Day 3: 150 mg in evening; maintenance 150-300 mg/day
• Elderly: Slower dose titration, lower therapeutic dose
• Hepatic impairment: 25 mg/day initially; increase by 25-50 mg

Side Effects:

• Somnolence
• Dizziness
• Dry mouth
• Weight gain
• Increased serum triglycerides
• Increased total cholesterol (LDL)
• Decreased HDL cholesterol
• Decreased hemoglobin
• Extrapyramidal symptoms
• Akathisia
• Dystonia
• Parkinsonism

• May affect driving ability; do not drive if drowsy or dizzy
• Discontinue if Neuroleptic Malignant Syndrome (fever, muscle rigidity, altered consciousness) occurs
• Rise slowly to avoid orthostatic hypotension
• May cause weight gain, increased blood sugar and cholesterol; monitor regularly
• Do not stop abruptly
• Risk of suicidal thoughts or behavior; monitor