৳ 48/unit
Pack: ৳ 672
৳ 48/unit
Pack: ৳ 672
At a glance
Tofacitinib is a Janus kinase inhibitor used to treat moderate to severe rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It helps decrease pain, tenderness, and swelling in the joints by reducing inflammation.
Indications
- Rheumatoid arthritis
- Psoriatic arthritis
- Ulcerative colitis
Pharmacology
Tofacitinib blocks the JAK-STAT pathway, preventing phosphorylation and activation of STATs. This reduces inflammatory response and immune cell function, providing therapeutic benefit in autoimmune diseases.
Dosage
Adult Dose (Oral):
- Rheumatoid arthritis: 5 mg twice daily
- Psoriatic arthritis: 5 mg twice daily
- Ulcerative colitis: 10 mg twice daily for at least 8 weeks, then 5 or 10 mg twice daily
- Moderate/severe renal or moderate hepatic impairment: 5 mg once daily
Side effects
Common Side Effects:
- Diarrhea
- Headache
- High blood pressure
- Nasal congestion
- Runny nose
- Sore throat
- Upper respiratory tract infection
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Avoid use during active serious infection
- May increase risk of serious infections
- Regular blood tests required
- Avoid live vaccines
- Monitor liver, kidney, blood counts, cholesterol
Overdose effects
Symptoms: Bone marrow suppression, infections.
Treatment: Supportive; no specific antidote.
Storage conditions
Store below 30°C; protect from light and moisture; keep out of reach of children.