৳ 25/unit
Pack: ৳ 250
৳ 25/unit
Pack: ৳ 250
At a glance
Topiramate is used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome. It controls seizures by decreasing abnormal and excessive activity of nerve cells in the brain.
Indications
- Epilepsy/Seizures
- Prevention of migraine
- Lennox-Gastaut syndrome
Pharmacology
Topiramate stimulates GABA-A receptor activity and reduces glutamate activity at AMPA and kainate receptors. It also blocks voltage-dependent sodium channels. These actions decrease neuronal excitability, preventing seizures and migraines.
Dosage
Adult Dose (Oral):
- Epilepsy monotherapy: 25 mg nightly initially; increase by 50 mg/day weekly; up to 200 mg twice daily
- Epilepsy adjunctive therapy: 25-50 mg/day initially; 100-200 mg twice daily
- Migraine prophylaxis: 25 mg nightly for 1 week; titrate to 50 mg twice daily over 4 weeks
- Renal impairment: Halve the dose
Side effects
Common Side Effects:
- Abdominal pain
- Diarrhea
- Dizziness
- Fatigue
- Fever
- Loss of appetite
- Memory impairment
- Nausea
- Sleepiness
- Weight loss
Use in pregnancy
Use in Pregnancy: Unsafe; definite evidence of risk to the developing baby; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- Regular monitoring of serum bicarbonate levels required
- Drink plenty of fluids to reduce risk of kidney stones
- Do not stop medication suddenly
- Report sudden mood changes or suicidal thoughts
Overdose effects
Symptoms: Severe metabolic acidosis.
Treatment: Gastric lavage, activated charcoal, supportive care; hemodialysis is effective.
Storage conditions
Keep below 30°C, away from light and moisture; keep out of reach of children.