Trubid500mg

• Streptococcal pharyngitis and tonsillitis
• Bronchopneumonia, bacterial pneumonia
• Uncomplicated urinary tract infections (pyelonephritis, cystitis)
• Skin and soft tissue infections (abscesses, furunculosis, impetigo, erysipelas, pyoderma, lymphadenitis)

Adults and Adolescents (>40 kg, normal renal function):
Streptococcal pharyngitis/tonsillitis: 1000 mg once daily for at least 10 days.
Bronchopneumonia, bacterial pneumonia, UTI, skin & soft tissue infections: 1000 mg twice daily. Max: 4 g/day.

Children (<40 kg, normal renal function):
Streptococcal pharyngitis/tonsillitis: 30 mg/kg/day (single dose), at least 10 days.
Other infections: 30-35 mg/kg/day (in 2 divided doses). Severe infections: up to 100 mg/kg/day.
Children under 6 years: 500 mg tablets not recommended; use suspension.

Renal impairment (Creatinine clearance):
25-50 mL/min/1.73m²: 500-1000 mg every 12 hours
10-25 mL/min/1.73m²: 500-1000 mg every 24 hours
<10 mL/min/1.73m²: 500-1000 mg every 36 hours

Hemodialysis: Additional 500-1000 mg dose after dialysis.

Hepatic impairment: No dose adjustment needed.

Elderly: Adjust dose based on renal function.

Note: Streptococcus pyogenes infections require 10 days of therapy. Continue treatment for 2-3 days after clinical symptoms resolve.

Common (>1%): Nausea, vomiting, diarrhea, dyspepsia, abdominal pain, glossitis, pruritus, rash, allergic exanthema, urticaria.

Uncommon (0.1-1%): Vaginal mycoses, thrush.

Rare (0.01-0.1%): Eosinophilia, thrombocytopenia, leukopenia, neutropenia, agranulocytosis, serum sickness-like reactions, cholestasis, idiosyncratic hepatic failure, arthralgia, interstitial nephritis, fever.

Very rare (<0.01%): Hemolytic anemia, anaphylactic shock, headache, insomnia, dizziness, nervousness, pseudomembranous colitis, Stevens-Johnson syndrome, erythema multiforme, fatigue.

Side effects are usually mild and transient.

• Prescribing in the absence of proven bacterial infection is unlikely to provide benefit and increases the risk of drug-resistant bacteria.
• Use with special caution in patients with non-severe hypersensitivity to penicillins (cross-allergy risk ~5-10%).
• Caution in patients with history of gastrointestinal disease, particularly colitis.
• If rash, itching, swelling of face/mouth, or difficulty breathing occurs, discontinue and inform your doctor.
• Prolonged use may result in superinfection with fungi (e.g., Candida).
• Severe and persistent diarrhea may indicate pseudomembranous colitis; discontinue and start appropriate treatment.
• Coombs' test may be transiently positive.
• Adjust dose based on renal function.
• Enzymatic methods should be used for urine glucose testing (reduction tests may give false-positive results).