৳ 11.50/unit
Pack: ৳ 46
৳ 11.50/unit
Pack: ৳ 46
At a glance
Dutasteride is used in the treatment of benign prostatic hyperplasia (BPH). It shrinks the size of the enlarged prostate gland to relieve symptoms like pain and difficulty in passing urine.
Indications
- Benign prostatic hyperplasia (BPH)
Pharmacology
Dutasteride is a dual inhibitor of 5α-reductase. It inhibits both type 1 and type 2 5α-reductase isoenzymes, which are responsible for the conversion of testosterone to 5α-dihydrotestosterone (DHT). DHT is the androgen primarily responsible for hyperplasia of glandular prostatic tissue.
Dosage
Adult Dose (Oral): 500 mcg once daily for at least 6 months.
Hepatic Dose: Severe: Contraindicated.
Renal Dose: Dose adjustment not necessary.
Side effects
Common Side Effects:
- Decreased sexual desire
- Impotence (trouble getting or keeping an erection)
- Decrease in amount of semen/sperm
- Testicle pain or swelling
- Increased breast size
- Breast tenderness
- Allergic reaction
Use in pregnancy
Dutasteride is highly unsafe during pregnancy. Studies have shown significant harmful effects to the developing baby.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Dutasteride shrinks the enlarged prostate and reduces the risk of urinary retention.
- It may take 3 to 6 months to see full beneficial effect.
- Usually well tolerated but may produce mild sexual side effects.
- Do not donate blood for 6 months after the last dose (to prevent administration to pregnant transfusion recipients).
- Pregnant or potentially pregnant women should not handle dutasteride capsules.
Overdose effects
Single doses up to 40 mg (80 times therapeutic dose) were safe in volunteer studies. No specific antidote.
Storage conditions
Store below 30°C, away from light & moisture. Keep out of reach of children.