৳ 10.07/unit
Pack: ৳ 100.70
৳ 10.07/unit
Pack: ৳ 100.70
At a glance
Venlafaxine is a prescription medicine used in the treatment of depression and anxiety disorder. It alters the chemicals in the brain that cause symptoms of anxiety such as irritability, restlessness, lack of concentration, fatigue, sweating, increased heart rate and unwanted or racing thoughts.
Indications
- Depression
- Anxiety disorder
- Panic disorder
- Social anxiety disorder
- Generalized anxiety disorder
Pharmacology
Venlafaxine and its active metabolite ODV are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. Venlafaxine and ODV have no significant affinity for muscarinic, histaminergic, or α-1 adrenergic receptors.
Dosage
Adult Dose (Oral):
- Depression: Initially 75 mg/day in 2-3 divided doses; increase by up to 75 mg/day at intervals of 4 days or more; max 375 mg/day
- Extended-release: Initially 37.5-75 mg once daily; after 4-7 days may increase to 75 mg once daily; max 225 mg/day
- Panic disorder: Extended-release 37.5 mg once daily for 1 week; after 7 days increase to 75 mg once daily; max 225 mg/day
- Anxiety: Extended-release 37.5-75 mg once daily; max 225 mg/day
- Hepatic impairment: Mild to moderate: reduce dose by 50%
- Renal impairment: GFR <30 mL/min or hemodialysis: reduce dose by 50%
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Dizziness
- Insomnia
- Decreased appetite
- Anxiety
- Constipation
- Increased sweating
- Sexual dysfunction
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect ability to drive
- May take 2-4 weeks to start working
- Avoid alcohol; may cause excessive drowsiness and increase risk of liver damage
- Talk to doctor if sudden mood changes or suicidal thoughts occur
- Do not stop medication suddenly
Overdose effects
Symptoms: Nausea, dizziness, tachycardia, serotonin syndrome.
Treatment: Supportive care.
Storage conditions
Store below 30°C in a dry place, protected from light; keep out of reach of children.