oshudhkosh

Veracal5mg/2ml

Rx
Dosage form:
Injection
Pack size:
Box (5 Injection)

৳ 30/unit

Pack: ৳ 150

At a glance

Verapamil Hydrochloride — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Verapamil Hydrochloride is used to treat angina (heart-related chest pain), high blood pressure and some types of irregular heartbeats (arrhythmia). It works by relaxing blood vessels to lower blood pressure. This helps to reduce the workload of the heart. Verapamil Hydrochloride may be taken with or without food, but it is better to take it regularly at a fixed time each day as advised by your doctor. Keep using this medicine even if you feel well. If you stop taking it suddenly, your condition may worsen. This medicine is only part of a treatment program that should include a healthy diet, regular exercise, and weight reduction as advised by your doctor. Common side effects seen with this medicine include swelling of the ankles or feet (oedema), dizziness, headache, nausea, constipation, flushing, rash, and fatigue. These are usually mild and disappear after a short time. Consult your doctor if they bother you or do not go away. It may also make you feel sleepy or dizzy, so be careful if you drive or do anything that requires you to be alert. Drinking alcohol should be avoided while taking this medicine as it may worsen the side effects. Before taking this medicine, let your doctor know if you have any liver or kidney problems. Also, inform your doctor if you have very low blood pressure (hypotension), heart failure, or if you recently had a heart attack and have fluid in your lungs. Your doctor may want to monitor your blood pressure while using it and you may need frequent blood tests. Pregnant or breast-feeding women should consult their doctor before taking it. Verapamil Hydrochloride is a calcium channel blocker. It blocks the action of calcium on the heart and blood vessels, thereby widening the blood vessels and allowing more blood and oxygen to reach the heart. This reduces blood pressure and decreases the chances of angina (chest pain).

Indications

• Hypertension (high blood pressure) • Angina (heart-related chest pain) • Arrhythmia

Mechanism of action

Verapamil inhibits entry of calcium ions into arterial smooth muscle cells as well as the myocytes and conducting tissue. These actions lead to reversal and preventions of coronary artery spasm, reduction in afterload through peripheral vasodilatation and reduction in ventricular rate in patients with chronic atrial flutter or fibrillation and reduction in the occurrence of paroxysmal supraventricular tachycardia. Verapamil reduces BP, relieves angina and slows AV conduction.

Dosage

Adult Dose: Oral Hypertension Adult: Immediate release 80 mg PO q8hr initially; maintenance: 80-320 mg PO q12hr Extended release 180 mg/day PO (120 mg/day initially if patient elderly or of small stature); for desired response, may be increased to 240 mg/day PO, then by 120 mg/day at weekly intervals; not to exceed 480 mg/day Angina Immediate release 80 mg PO q8hr initially; usual range: 80-120 mg PO q8hr; not to exceed 480 mg/day Extended release 180 mg/day PO at bedtime initially; maintenance: 180-480 mg/day PO at bedtime Chronic Atrial Fibrillation & Paroxysmal Supraventricular Tachycardia Treatment of chronic atrial fibrillation (rate control); prevention of paroxysmal supraventricular tachycardia Immediate release: 240-480 mg/day PO divided q6-8hr Tardive Dyskinesia 40 mg PO q8hr; may be titrated to 120 mg q8hr Intravenous 2.5-5 mg IV over 2 minutes; 5-10 mg dose may be repeated after 15-30 minutes Alternatively, 0.075-0.15 mg/kg (not to exceed 10 mg) IV over 2 minutes; dose may be repeated once 30 minutes after first dose Hepatic impairment: In cirrhosis, reduce dose by 20-50% of normal for oral and IV administration Child Dose: Supraventricular Tachycardia 1-15 years old: 0.1-0.3 mg/kg (not to exceed 5 mg) IV over 2 minutes; second dose (not to exceed 10 mg) may be given after 30 minutes Alternatively (not well established), 4-8 mg/kg/day PO divided q8hr Renal Dose: Renal impairment: Use with caution; monitor ECG; for Verelan PM, manufacturer recommends 100 mg at bedtime initially; if CrCl <10 mL/min, reduce dose by 25-50%

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Verapamil Hydrochloride is to be taken with food.

Side effects

Common: • Headache • Constipation • Infection • Dizziness • Sinus infection • Flu-like symptoms • Peripheral edema

Precautions & warnings

[UNSAFE] Verapamil Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause you to feel lightheaded or weak especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down. It is best to avoid drinking alcohol while taking Verapamil Hydrochloride as it may make the side effects worse.

Contraindications

Cardiogenic shock, hypotension (systolic pressure <90 mmHg), marked bradycardia, uncompensated heart failure, 2nd- or 3rd-degree AV block (unless pacemaker is fitted), sick-sinus syndrome, severe ventricular dysfunction, atrial flutter or atrial fibrillation and accessory bypass tract (e.g. Wolff-Parkinson-White, Lown-Ganong-Levine syndromes).

Drug interactions

Increased cardiac depressant effects with beta-blockers and flecainide. Increased risk of additive bradycardia, conduction disturbances and digoxin toxicity with digoxin. Increased risk of bradycardia and hypotension with remifentanil and sufentanil. Increased levels of both everolimus and verapamil on concurrent use. May increase doxorubicin, buspirone, carbamazepine, ciclosporin, epirubicin, eplerenone, quinidine, statins, sirolimus, tacrolimus, quinupristin/dalfopristin levels. Verapamil increase blood alcohol levels. Unpredictable interactions with lithium. Decreased verapamil concentrations with phenobarbital, sulfinpyrazone, rifampicin, rifabutin and rifapentine. Increased verapamil concentrations with protease inhibitors and cimetidine. Potentially Fatal: Increased cardiac depressant effects with amiodarone. Increased risk of QT prolongation with dofetilide, ranolazine, sertindole. Additive bradycardia with ivabradine. Increased risk of heart block with clonidine. Increased risk of acute hyperkalaemia and CV collapse with dantrolene.

Food interactions

[UNSAFE] It is unsafe to consume alcohol with Verapamil Hydrochloride.

Use in pregnancy

[CONSULT YOUR DOCTOR] Verapamil Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[SAFE IF PRESCRIBED] Verapamil Hydrochloride is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Renal / hepatic impairment

[CAUTION] Verapamil Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Verapamil Hydrochloride may be needed. Please consult your doctor. Careful monitoring of the patient for any signs of overdosage is advisable. [CAUTION] Verapamil Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Verapamil Hydrochloride may be needed. Please consult your doctor.

Common questions

What is heart attack? When heart attack coming? Related to chest pain angina commonly Heart pain blood pressure high blood sugar high Consult physician near u for proper examination and blood work up I am having pain in left side of the chest also in left arm is it related to heart attack what can be done get relief ?? Please consult to your nearest doctor for blood pressure examination. then let me know. I am a patient of hypertension Hypertension is clinal condition of high blood pressure. Please see a physician. Which tablet is best for high blood pressure.I am taking telmisim 40 Which tablet is best for high blood pressure. I am taking telmisim 40 Depends on your blood pressure range kidney and heart functions Some times I had lot of hypertension Hypertension is clinically high blood pressure. Persistent high arterial blood pressure above 120/80 mm HG is termed as pre-hypertension or hypertension, but the point to be emphasized is that this rise in blood pressure is persistent. Transient increase in BP occurs in stress and anxiety and needs to be treated accordingly.

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.