Vonliv 10

• Gastric ulcer
• Duodenal ulcer
• Reflux esophagitis
• Prevention of recurrence of gastric or duodenal ulcer during low-dose aspirin administration
• Prevention of recurrence of gastric or duodenal ulcer during NSAID administration
• Adjunct to Helicobacter pylori eradication

Adult Dose (Oral):

• Gastric ulcer: 20 mg once daily for 8 weeks
• Duodenal ulcer: 20 mg once daily for 6 weeks
• Reflux esophagitis: 20 mg once daily for 4 weeks; may extend up to 8 weeks
• Maintenance of reflux esophagitis: 10 mg once daily; may increase to 20 mg once daily
• Prevention of ulcer recurrence during low-dose aspirin or NSAID: 10 mg once daily
• H. pylori eradication: 20 mg + amoxicillin 750 mg + clarithromycin 200 mg twice daily for 7 days

Common Side Effects:

• Diarrhea
• Constipation
• Drug hypersensitivity (including anaphylactic shock)
• Drug eruption
• Urticaria
• Hepatotoxicity
• Jaundice
• Rash
• Nausea
• Abdominal distension
• Abnormal liver function tests
• Edema
• Eosinophilia

Use in Pregnancy: Use only if the expected therapeutic benefit is thought to outweigh any possible risk.

• The course of the disease should closely be observed and the minimum therapeutic necessity should be used
• In long-term treatment, close observation by such means as endoscopy should be made
• In maintenance of healing of reflux esophagitis, administer only to patients who repeat recurrence and recrudescence
• Unknown if alters ability to drive; caution advised

Symptoms: No experience of overdose; not removed by hemodialysis.

Treatment: Symptomatic and supportive.