৳ 526.50/unit
Pack: ৳ 8,424
৳ 526.50/unit
Pack: ৳ 8,424
At a glance
Trelagliptin is indicated for type 2 diabetes mellitus when the first line treatment of metformin is not achieving the expected glycemic goals.
Indications
- Type 2 diabetes mellitus
Pharmacology
Trelagliptin selectively inhibits human plasma DPP-4 activity (IC50: 4.2 nmol/l). It inactivates GLP-1, increasing active GLP-1 concentration, which promotes glucose-dependent insulin secretion and improves glucose tolerance.
Dosage
Adult Dose (Oral):
- 100 mg tablet once weekly
- Moderate renal impairment (CrCl 30-<50): 50 mg once weekly
Side effects
Common Side Effects:
- Hypoglycemia
- Nasopharyngitis
- Elevated lipase
- Acute pancreatitis
- Intestinal obstruction
- Atrial fibrillation
- Elevated liver enzymes
Use in pregnancy
Use in Pregnancy: Safety not established; use only after risk-benefit evaluation.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in moderate kidney function disease
- Caution in hypoadrenalism or hypopituitarism
- Caution in malnutrition, irregular eating patterns, starvation, vigorous exercise
- May cause hypoglycemia when used with other diabetes medication
- Consider reducing dose of sulfonylurea or insulin when used in combination
Overdose effects
Symptoms: Hypoglycemia, QT elongation (at 800 mg dose).
Treatment: Supportive; correct hypoglycemia with sucrose.
Storage conditions
Store at 25°C; excursions permitted to 15-30°C. Dispense in original container to protect from high humidity and light; keep out of reach of children.