Xefer 100mg IV

• Iron Deficiency Anemia: Used for treatment of IDA in adults who have intolerance or unsatisfactory response to oral iron; also for IDA in adults with non-dialysis dependent CKD.

Ferric Carboxymaltose is a colloidal iron (III) hydroxide in complex with Carboxymaltose, a carbohydrate polymer that releases iron; replaces iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin.

Adult Dose (IV):

• >50 kg: 750 mg IV once, follow 7 days later with second 750 mg dose; not to exceed cumulative dose of 1500 mg per course.
• <50 kg: 15 mg/kg IV once, follow 7 days later with second dose; not to exceed 1500 cumulative dose per course.
• Single administration: 15 mg iron/kg (IV injection) or 20 mg/kg (IV infusion); max 1000 mg; max 1000 mg per week.

Common Side Effects:

• Injection site reactions (pain, swelling, redness)
• Nausea
• Vomiting
• Dark colored stool
• Headache
• Dizziness
• Flushing
• Hypertension
• Aminotransferase increased
• Hypophosphataemia

Use in Pregnancy: Ferric Carboxymaltose may be unsafe; animal studies suggest effects on fetal skeletal development; should be confined to second and third trimester if benefit outweighs risk.

Precautions:

• Ferric Carboxymaltose does not usually affect your ability to drive.
• Observed for at least 30 minutes after each injection due to risk of allergic reaction.
• Blood pressure and blood iron levels will be regularly monitored during treatment.
• Inform doctor if taking any oral iron-containing products.
• Avoid alcohol (may worsen side effects).
• Stools may become black or dark in color (normal and harmless).

Overdose: Excessive dosages may lead to accumulation of iron in storage sites potentially leading to hemosiderosis; monitor serum ferritin and transferrin saturation; consider use of iron chelator.

Storage: Store below 30 degree C in a cool and dry place, away from light. Do not freeze. Keep out of reach of children.