৳ 5.91/unit
Pack: ৳ 5.91
৳ 5.91/unit
Pack: ৳ 5.91
At a glance
Hydrochlorothiazide + Losartan Potassium combination is used for the treatment of hypertension and to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy.
Indications
- Hypertension (high blood pressure)
- Reduction of stroke risk in patients with hypertension and left ventricular hypertrophy
Pharmacology
Losartan and its active metabolite selectively block the AT1 receptor of angiotensin II, inhibiting vasoconstriction and aldosterone secretion. Hydrochlorothiazide inhibits sodium and chloride reabsorption in the distal convoluted tubule, increasing sodium and chloride excretion, which reduces plasma volume and activates the renin-aldosterone system.
Dosage
Adult Dose (Oral):
- Hypertension: Initial: 50 mg/12.5 mg once daily; may increase to 100 mg/25 mg if needed
- Severe Hypertension: Starting dose: 50/12.5 once daily; may increase to 100/25 after 2-4 weeks if needed
- Hypertension with LVH: Initial: 50/12.5; may increase to 100/12.5, then 100/25 if needed; Max: 100/25 once daily
- Volume Depletion: Start with losartan 25 mg once daily
- Elderly: Initial dose 50/12.5; Max 100/25 should not be used as initial therapy
Renal Dose: CrCl >30 mL/min: No dosage adjustment; not recommended in severe renal impairment
Side effects
Common Side Effects:
- Dizziness
- Nausea
- Taste change
- Upset stomach
- Diarrhea
- Headache
- Weakness
- Decreased blood pressure
- Glucose intolerance
- Increased blood uric acid
- Electrolyte imbalance
Others: Vertigo, angioedema, hyperkalemia, gastrointestinal disturbances, angina, palpitation, dyspnea, hepatitis, atrial fibrillation, syncope, pancreatitis, cough, erectile dysfunction, renal impairment
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; angiotensin-II receptor antagonists should be avoided in pregnancy; may adversely affect fetal and neonatal blood pressure control and renal function; contraindicated in pregnancy.
Precautions & warnings
Precautions:
- Hydrochlorothiazide + Losartan may decrease alertness, affect vision or make you feel sleepy and dizzy; do not drive if these symptoms occur
- May cause dehydration; drink plenty of fluids; inform doctor if extreme thirst, very dry mouth or muscle weakness develops
- May cause dizziness; get up slowly when rising from a sitting or lying position
- Not safe during pregnancy and breastfeeding
- Angioedema: caution
- Periodic determination of serum electrolytes
- Hypokalemia may rarely develop; with severe cirrhosis or after prolonged therapy
- Renal impairment and symptomatic hypotension
Overdose effects
Overdose: Losartan: Hypotension and tachycardia; bradycardia may occur; not removed by hemodialysis. Hydrochlorothiazide: Electrolyte depletion (hypokalemia, hypochloremia) and dehydration; hypokalemia with digitalis may accentuate cardiac arrhythmias; symptomatic treatment.
Storage conditions
Store below 30°C; keep out of reach of children.