Xioclon 0.5

• Panic disorder (with or without agoraphobia)
• Lennox-Gastaut Syndrome (petit mal variant)
• Akinetic and myoclonic seizures
• Absence seizures (petit mal) - in patients who have failed to respond to succinimides

Clonazepam exhibits pharmacological properties which are common to benzodiazepines and include anticonvulsive, sedative, muscle relaxing and anxiolytic effects. The central actions of benzodiazepines are mediated through an enhancement of the GABAergic neurotransmission at inhibitory synapses. In the presence of benzodiazepines the affinity of the GABA receptor for the neurotransmitter is enhanced through positive allosteric modulation resulting in an increased action of released GABA on the postsynaptic transmembrane chloride ion flux.

Adult Dose (Oral - Epilepsy): Initial: 1 mg at night (4 days), gradually increased over 2-4 weeks; Maintenance: 4-8 mg/day; Max: 20 mg/day.

Adult Dose (Oral - Panic Disorder): Initial: 0.25 mg twice daily, increased after 3 days up to 1 mg/day; Max: 4 mg/day.

Pediatric Dose (Oral - Epilepsy): <10 years or <30 kg: 0.01-0.03 mg/kg/day (max 0.05 mg/kg/day) in 2-3 divided doses; increase by max 0.25-0.5 mg every 3rd day; Maintenance: 0.1-0.2 mg/kg/day (3 divided doses); Max: 0.2 mg/kg/day.

IV Dose (Status Epilepticus): Adult: 1 mg slow IV (over 2 min); Child: 500 mcg slow IV.

Elderly: Initial: 0.5 mg at night (4 days).

Common Side Effects (in seizure treatment): Drowsiness (approx 50%), Ataxia (approx 30%), Behavioral problems (approx 25%)

Other Side Effects: Depression, dizziness, fatigue, impaired coordination, abnormal eye movements, aphonia, coma, tremor, vertigo, confusion, amnesia, hallucinations, hysteria, increased libido, insomnia, psychosis, palpitations.

[CONSULT YOUR DOCTOR] Clonazepam is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. Pregnancy Category D. Administration of high doses in the last trimester may cause neonatal hypothermia, hypotonia, respiratory depression, and poor feeding.

• [UNSAFE] Clonazepam may cause side effects which could affect your ability to drive.
• The addiction/habit-forming potential is very high; take only as per the dose and duration advised by your doctor.
• Avoid consuming alcohol as it may increase dizziness and drowsiness.
• Inform your doctor if you experience worsening anxiety, depression, anger, violent behavior, or mania.
• Do not stop taking suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.
• Caution during pregnancy and lactation.

Overdose symptoms: Drowsiness, ataxia, dysarthria, nystagmus, areflexia, apnea, hypotension, cardiorespiratory depression, coma. Treatment: Symptomatic and supportive; flumazenil (benzodiazepine antagonist) may be used.

Keep in a dry place away from light and heat. Keep out of reach of children.