৳ 150/unit
Pack: ৳ 150
৳ 150/unit
Pack: ৳ 150
At a glance
Generic Name: Zonisamide Dosage Form: Capsule Therapeutic Class: Adjunct Anti-Epileptic Drugs Pharmacological Class: Anticonvulsant / Sulfonamide derivative Indications: Used as adjunctive therapy for the treatment of partial seizures in adults with epilepsy. Mechanism of Action: Modulates sodium and calcium channels, stabilizing neuronal membranes and reducing abnormal neuronal activity. Prescription Status: Prescription Medicine
Indications
• Epilepsy/Seizures
Pharmacology
The exact mechanism of Zonisamide is not fully understood. It acts on sodium and calcium channels, stabilizing neuronal membranes and reducing abnormal neuronal firing. It also inhibits carbonic anhydrase, which may cause metabolic acidosis.
Dosage
Adult Dose: Oral Adjunct in partial seizures Adult: Initially, 50 mg daily in 2 divided doses, increase to 100 mg daily after 1 wk. Thereafter, may further increase dose at wkly intervals in increments of up to 100 mg. Usual maintenance dose: 300-500 mg daily, some patients may respond to lower doses. Monotherapy for partial seizures with or without secondary generalisation Adult: In patients w/ newly diagnosed epilepsy: Initially, 100 mg once daily, increase to 200 mg once daily after 2 wk. May further increase by increments of 100 mg at intervals of at least 2 wk. Usual maintenance dose: 300 mg once daily, up to 500 mg daily. Hepatic impairment: Mild to moderate: Slower dosage titration may be needed. Severe: Not recommended. Child Dose: Oral Adjunct in partial seizures Child: >6 yr Initially, 1 mg/kg once daily for 1 wk, may increase by increments of 1 mg/kg at wkly interval. Usual maintenance dose: 20-55 kg: 6-8 mg/kg once daily; >55 kg: 300-500 mg once daily, some may respond to lower dose. Renal Dose: Renal impairment: GFR ?50 mL/min: Slower dosage titration may be needed. GFR <50 mL/min: Not recommended.
Side effects
Common: • Dizziness • Loss of appetite • Memory impairment • Drowsiness • Impaired concentration • Altered walking • Impaired coordination • Anger
Use in pregnancy
[CONSULT YOUR DOCTOR] Zonisamide may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Precautions & warnings
[UNSAFE] Zonisamide may cause side effects which could affect your ability to drive. As Zonisamide may affect your concentration, ability to react/respond, and may make you feel sleepy, particularly at the beginning of your treatment or after your dose is increased. Take your medication regularly as directed by your doctor as missing doses can trigger seizures. Do not change the brand of your medicine and make sure that you have sufficient amount of medicine present with you. Some healthy tips to prevent seizures: Do not drive or do anything that requires mental focus until you know how this medicine affects you. Drink plenty of water while taking Zonisamide to reduce the risk of kidney stones and heat stroke. Inform your doctor if you have sudden pain in your stomach, pain on urinating, or if you find blood in your urine. It may cause loss of appetite and weight. Monitor your weight regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.
Overdose effects
Overdose may cause: Severe drowsiness Coma Bradycardia Hypotension Respiratory depression
Storage conditions
Store in a dry place. Protect from light. Keep out of reach of children.