৳ 44,451/unit
Pack: ৳ 44,451
৳ 44,451/unit
Pack: ৳ 44,451
At a glance
Goserelin is used for prostate cancer, breast cancer, endometriosis and uterine fibroids.
Indications
- Stage B2-C Prostatic Carcinoma: in combination with flutamide prior to and during radiation therapy
- Advanced Prostatic Carcinoma: palliative treatment
- Endometriosis: pain relief and reduction of lesions (6 months)
- Endometrial Thinning: prior to endometrial ablation
- Advanced Breast Cancer: palliative treatment in pre- and perimenopausal women
Pharmacology
Goserelin is a synthetic decapeptide analogue of GnRH. Goserelin acts as an inhibitor of pituitary gonadotropin secretion when administered in the biodegradable formulation. In animal and in vitro studies, administration of goserelin resulted in the regression or inhibition of growth of the hormonally sensitive dimethylbenzanthracene (DMBA)-induced rat mammary tumor and Dunning R3327 prostate tumor.
Dosage
Goserelin 3.6 mg:
- SC injection into anterior abdominal wall every 28 days
- Prostate cancer: long-term administration
- Endometriosis: 6 months
- Endometrial thinning: 1 or 2 depots (4 weeks apart)
- Breast cancer: long-term administration
Goserelin 10.8 mg:
- SC injection into anterior abdominal wall every 12 weeks
- Prostate cancer: long-term administration
* Use as directed by the registered physician
Side effects
Common Side Effects (Men >10%):
- Hot flashes
- Sexual dysfunction
- Decreased erections
- Lower urinary tract symptoms
Common Side Effects (Women >20%):
- Hot flushes
- Headache
- Sweating
- Acne
- Emotional lability
- Depression
- Decreased libido
- Vaginitis
- Breast atrophy
Use in pregnancy
Use in Pregnancy: Highly unsafe during pregnancy. Studies have shown significant harmful effects to the developing baby.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Tumor Flare Phenomenon - symptoms may temporarily worsen in first few weeks
- Hyperglycemia and diabetes risk - monitor blood glucose
- Cardiovascular disease risk - monitor and manage
- Hypercalcemia - monitor in patients with bone metastases
- QT interval may be prolonged - consider risks and benefits
Overdose effects
Overdose: Limited information available on overdose. Employ usual supportive measures.
Storage conditions
Storage: Keep away from light and moisture. Keep out of reach of children.