Zolomide250mg

Temozolomide Hydrochloride is used in the treatment of a specific type of cancer of the brain. It is used to treat brain tumors if they return or get worse after standard treatment. It may be also used to treat other conditions, as determined by the doctor. Temozolomide Hydrochloride should be taken empty stomach and at same time each day to make sure it has the best effect. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, constipation, headache and fatigue. This medicine may reduce the number of blood cells in your blood thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with kidney, liver and heart function during treatment with this medicine. Before taking it, tell your doctor if have bleeding, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Temozolomide Hydrochloride is an anti-cancer medication. It enters the brain tissues and works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

• Brain tumor

Temozolomide, a triazene, is an inactive prodrug. It is chemically hydrolysed to 3-methyl-(triazen-1-yl) imidazole-4-carboxamide (MTIC), the active metabolite of dacarbazine. The cytotoxicity of MTIC is believed to be due alkylation of DNA, mainly at the O6 and N7 positions of guanine.

Adult Dose: Oral Glioblastoma multiforme Adult: 75 mg/m2 once daily for 42 days with focal radiotherapy (concomitant phase). Do not reduce dose during concomitant phrase but interrupt or discontinue therapy depending on toxicity. Continue if absolute neutrophil count (ANC)> 1.5x109/L, thrombocyte count >100x109/L and Common Toxicity Criteria (CTC) non-haematological toxicity 1.5x109/L, thrombocyte count >100x109/L and CTC non-haematological toxicity for cycle 1 is 1500 mm³ and platelets >100,000 mm³ Infuse IV over 90 minutes Dosage modifications Measure ANC and platelet on days 22 & 29 (day 1 of next cycle); modify dose for following cycle if: ANC 1000-1500/mm³ or platelet 50,000-100,000/mm³: Postpone treatment until ANC >1500/mm³ and platelet >100,000/mm³; maintain initial dose ANC 1,500/mm³ and platelets >100,000/mm³ -Decrease dose by 50 mg/m²/day for subsequent cycles -Do NOT administer drug at dose <100 mg/m² for anaplastic astrocytoma Decrease maintenance dose Reduce from 200 mg/m²/day to 150 mg/m²/day and from 150 mg/m²/day to100 mg/m²/day if: -ANC< 10,000/mm³ -Platelets <50,000/mm² -CTC Grade 3 non-hematologic toxicity Recurrent or progressive malignant gliomas Adult: Previously untreated with chemotherapy: 200 mg/m2 once daily for 5 days, followed by a 23 day break (1 cycle). Previously treated with chemotherapy: 150 mg/m2 daily for 5 days followed by 23 day break (1 cycle) increased to 200 mg/m2 daily for the 2nd cycle if there is no haematological toxicity. Metastatic melanoma Adult: 200 mg/m2 daily for 5 days every 28 days. Child Dose: Oral Recurrent or progressive malignant gliomas Child: >3 yr: Previously untreated with chemotherapy: 200 mg/m2 once daily for 5 days, followed by a 23 day break (1 cycle). Previously treated with chemotherapy: 150 mg/m2 daily for 5 days followed by 23 day break (1 cycle) increased to 200 mg/m2 for the 2nd cycle if there is no haematological toxicity.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Temozolomide Hydrochloride is to be taken empty stomach.

If you miss a dose of Temozolomide Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Vomiting • Constipation • Headache • Fatigue • Convulsion • Coordination disorder • Diarrhea • Dizziness • Fever • Hair loss • Hemiparesis (weakness on one side of the body) • Insomnia (difficulty in sleeping) • Loss of appetite • Memory loss • Rash • Viral infection • Weakness

[UNSAFE] Temozolomide Hydrochloride may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Swallow full tablets on an empty stomach, one hour before your meal. Avoid being near people who are sick or have infections. Consult your doctor if you develop symptoms of opportunistic infections (such as Pneumocystis jirovecii pneumonia) and reactivation of infections (such as hepatitis B virus) Using temozolomide may increase your risk of developing certain types of bone marrow cancer. Be aware about your specific risk. You may be given medication to prevent nausea or other side effects while you are receiving temozolomide. Your blood will be tested frequently during treatment to monitor the side effects of temozolomide on your blood cells as you may have a small risk of other changes in blood cells, including leukemia. Avoid activities that may increase your risk of bleeding or injury. Use extra care to prevent bleeding while shaving or brushing your teeth. Do not drink alcohol while taking temozolomide. Do not drive or operate machinery while using temozolomide as it may make you tired or sleepy. Both male and female patients should take effective contraceptive precautions during and after 6 months of treatment. Male patients should seek advice on conservation of sperm prior to treatment as temozolomide treatment may cause infertility.

Hypersensitivity to dacarbazine. Severe myelosupression. Pregnancy.

Valproic acid, other myelosuppressive agents.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Temozolomide Hydrochloride. Please consult your doctor.

[CONSULT YOUR DOCTOR] Temozolomide Hydrochloride is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Temozolomide Hydrochloride is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Temozolomide Hydrochloride is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Temozolomide Hydrochloride may not be needed in these patients. Please consult your doctor. Cautious use is advised in patients with severe kidney disease while they are taking Temozolomide Hydrochloride. [CAUTION] Temozolomide Hydrochloride should be used with caution in patients with severe liver disease. Dose adjustment of Temozolomide Hydrochloride may be needed. Please consult your doctor. Limited information is available on the use of Temozolomide Hydrochloride in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

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