Alendronic Acid + Vitamin D3

Alendronic Acid + Vitamin D3 is prescribed to treat osteoporosis. It prevents bone loss and helps in thickening of the bones. It also strengthens the muscles to support the body. It is a potent medicine used to prevent bone loss in women after menopause by rebuilding their bones. Alendronic Acid + Vitamin D3 is best taken in an empty stomach. You should take it regularly at a fixed time each day. Taking it at the same time every day will help you remember to take it. It may take several days to get the full benefit of this drug. Do not stop taking the medicine until your doctor tells you it is alright to stop. This medicine may only be part of a treatment program that may also include changes to your diet and taking other medicines and vitamin supplements. The most common side effects of this medicine include headache, back pain, musculoskeletal (bone, muscle or joint) pain, indigestion, heartburn, and diarrhea. These are generally mild and usually resolve on their own. If they do not go away or get worse, you should let your doctor know. Your doctor may be able to suggest ways of preventing or reducing the side effects. Before using this medicine, let your doctor know if you have any medical conditions or disorders. To make sure the medicine is safe for you, let your doctor also know all the other medicines you are taking. You may need frequent medical tests to check your kidney function and mineral levels while on treatment with this medicine. You should avoid consuming large amounts of alcohol, as it can cause bone loss. Pregnant and breastfeeding mothers should consult their doctors before using this medicine. Alendronic Acid + Vitamin D3 is a combination of two medicines: Alendronic Acid and Vitamin D3 which treat osteoporosis. Alendronic Acid is a bisphosphonate. It works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimizes the risk of fractures. Vitamin D3 helps protect your bones, both by increasing calcium absorption and by supporting muscles needed to avoid falls.

• Treatment of osteoporosis in postmenopausal women: Reduces the risk of vertebral and hip fractures. • Treatment of osteoporosis in men: Increases bone mass and reduces the incidence of fractures. • Treatment of glucocorticoid-induced osteoporosis. • Correction of vitamin D deficiency in patients with osteoporosis.

বিসফসফোনেট + ভিটামিন ডি সাপ্লিমেন্ট (Combined preparations: Inhibiting bone resorption)

Alendronic acid is a bisphosphonate that acts as a specific inhibitor of osteoclast-mediated bone resorption . It preferentially localizes to sites of bone resorption and inhibits osteoclast activity, resulting in bone formation exceeding bone resorption and progressive gains in bone mass . Vitamin D3 (colecalciferol) is the natural precursor of the calcium-regulating hormone calcitriol, which enhances intestinal absorption of calcium and phosphate and supports bone mineralization . Vitamin D insufficiency leads to negative calcium balance, increased parathyroid hormone levels, bone loss, and increased fracture risk .

Alendronic Acid + Vitamin D3 is a combination of two medicines: Alendronic Acid and Vitamin D3 which treat osteoporosis. Alendronic Acid is a bisphosphonate. It works by suppressing the activity of osteoclasts, cells that cause destruction of bone. This strengthens the bone and minimizes the risk of fractures. Vitamin D3 helps protect your bones, both by increasing calcium absorption and by supporting muscles needed to avoid falls.

Adult Dose: Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min. Renal Dose: Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Alendronic Acid + Vitamin D3 is to be taken empty stomach.

• If a weekly dose is missed: Take 1 tablet the morning after you remember, then return to your regular weekly schedule. • Do not take 2 tablets on the same day.

Common: • Headache • Musculoskeletal (bone, muscle or joint) pain • Back pain • Indigestion • Diarrhea • Heartburn

[UNSAFE] Alendronic Acid + Vitamin D3 may cause side effects which could affect your ability to drive. Alendronic Acid + Vitamin D3 is not expected to have any effects but in rare cases, it may cause dizziness, severe muscle, joint and bone pain and eye pain or inflammation. This may affect your ability to drive. Alendronic Acid + Vitamin D3 is used in the treatment of osteoporosis Take it on the same day each week, in the morning, at least 30 minutes before eating or drinking anything. Maintain an upright posture for 30 minutes after taking the medication so the medicine doesnot irritate your food pipe. Take care of your teeth and jaw while taking the Alendronic Acid + Vitamin D3 and for regular dental checkup while taking Alendronic Acid + Vitamin D3. Take calcium and vitamin enriched diet. Side effects such as headache, back pain and indigestion may occur.

• Esophageal abnormalities that delay esophageal emptying, such as stricture or achalasia. • Inability to sit upright or stand for at least 30 minutes. • Hypersensitivity to alendronic acid, cholecalciferol, or any of its components. • Hypocalcemia (low blood calcium levels).

Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for <30 min. Pregnancy, lactation.

Caution is advised when consuming alcohol with Alendronic Acid + Vitamin D3. Please consult your doctor.

[CONSULT YOUR DOCTOR] Alendronic Acid + Vitamin D3 may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Alendronic Acid + Vitamin D3 is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. If you are taking Alendronic Acid + Vitamin D3 during breastfeeding, monitor baby's blood calcium levels during the first two months.

Not recommended for use in children and adolescents due to lack of safety and efficacy data.

No dosage adjustment is necessary for elderly patients.

Alendronic Acid + Vitamin D3 is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Alendronic Acid + Vitamin D3 may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Alendronic Acid + Vitamin D3 is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Alendronic Acid + Vitamin D3 may not be needed in these patients. Please consult your doctor.

Alendronate overdose may cause hypocalcemia, hypophosphatemia, and upper gastrointestinal problems such as stomach upset, heartburn, and esophagitis. Milk or antacids may help bind alendronate. Do not induce vomiting, and keep the patient upright. Symptoms of vitamin D toxicity may include hypercalcemia, hypercalciuria, anorexia, nausea, polyuria, and weakness.

Store at 20-25°C, protected from light and moisture, in a cool and dry place. Keep out of reach of children.