Generic
Azilsartan + Chlorthalidone
2 brands available in the market
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Sorted from cheapest to most expensive
| Brand | Company | Form | Price/unit |
|---|---|---|---|
| Azilpres Plus40mg+12.5mg | Incepta Pharmaceuticals Ltd. | Tablet | ৳ 22 |
| Azisan Plus40mg+12.5mg | Renata Limited | Tablet | ৳ 22 |
At a glance
Azilsartan + Chlorthalidone — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Azilsartan + Chlorthalidone is a combination medicine used in the treatment of hypertension (high blood pressure). It works by relaxing the blood vessels and making the heart more efficient at pumping blood throughout the body. It also removes extra water and certain electrolytes from the body. Azilsartan + Chlorthalidone can be taken with or without food, but take it at the same time to get the most benefit. It should be taken as your doctor's advice. The dose and how often you take it depends on what you are taking it for. Never skip any doses and finish a full course of treatment even if you feel better. It is important that this medication is not stopped suddenly without talking to the doctor as it may worsen your symptoms. It may cause side effects like tiredness, decreased potassium level in blood, decreased blood pressure, increased creatinine level in blood, and increased uric acid level in blood. It is advised to drink plenty of fluids while taking this medicine. It may cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Regular monitoring of blood pressure is required while taking this medicine. Before taking this medicine, tell your doctor if you are pregnant or breastfeeding if you have ever had any problems with your blood circulation or have liver or kidney problems. Your doctor should also know about all other medicines you are taking as many of these may make this medicine less effective or change the way it works. Azilsartan + Chlorthalidone is a combination of two medicines: Azilsartan medoxomil and Chlorthalidone which lower blood pressure effectively. Azilsartan medoxomil is an angiotensin receptor blocker (ARB). It works by blocking the hormone angiotensin thereby relaxing blood vessels.This allows the blood to flow more smoothly and the heart to pump more efficiently. Chlorthalidone is a diuretic that removes extra water and certain electrolytes from the body. Over time it also relaxes blood vessels and improves blood flow.
Indications
• Hypertension (high blood pressure)
Mechanism of action
Angiotensin II blocker; displaces angiotensin II from AT1 receptor and may lower blood pressure by antagonizing AT1-induced vasoconstriction, aldosterone release, catecholamine release, arginine vasopressin release, water absorption, and hypertrophic responses Chlorthalidone produces diuresis with increased excretion of sodium and chloride at the cortical diluting segment of the ascending limb of Henle’s loop of the nephron
Dosage
Adult Dose: Adult Oral Hypertension 1 tab (40 mg/12.5 mg) once daily. May increase to 40 mg/25 mg after 2-4 weeks as needed to achieve blood pressure goals; not to exceed 40 mg/25 mg daily Switching from ARB or diuretic monotherapy: Initiate with 40 mg/12.5 mg PO qDay Hepatic impairment Mild-to-moderate: No dose adjustment required for azilsartan Severe: Azilsartan has not been studied in patients with severe hepatic impairment Chlorthalidone may cause mild alterations of fluid and electrolyte balance that may precipitate hepatic coma in patients with impaired hepatic function or progressive liver disease Child Dose: Safety and efficacy not established Renal Dose: Renal impairment Mild-to-moderate (eGFR 30 mL/min/1.73 sq.meter or greater): No dose adjustment required Severe (eGFR <30 mL/min/1.73 sq.meter): Safety and effectiveness not established Chlorthalidone may precipitate azotemia
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Azilsartan + Chlorthalidone may be taken with or without food, but it is better to take it at a fixed time.
Side effects
Common: • Dizziness • Tiredness • Decreased potassium level in blood • Decreased blood pressure • Increased creatinine level in blood • Increased uric acid level in blood
Precautions & warnings
[UNSAFE] Azilsartan + Chlorthalidone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Azildac CT Tablet for the treatment of high blood pressure. It can be taken with or without food. Azildac CT Tablet may cause dehydration. Drink plenty of fluids and inform your doctor if you develop extreme thirst, very dry mouth or muscle weakness. It may cause dizziness. Get up slowly when rising from a sitting or lying position. Use of Azildac CT Tablet during pregnancy or breastfeeding is unsafe. It may also decrease the risk of stroke and heart attacks.
Contraindications
Hypersensitivity. Patient w/ anuria. Concomitant use w/ aliskiren in patients w/ diabetes. Pregnancy.
Drug interactions
Elderly, vol-depleted patients or w/ compromised renal function, co-administration of NSAIDs, including selective COX-2 inhibitors, w/ angiotensin II receptor antagonists (including azilsartan) may result in deterioration of renal function, including possible acute renal failure. Dual blockade of the renin angiotensin system w/ angiotensin receptor blockers, ACE inhibitors or aliskiren is associated w/ increased risks of hypotension, hyperkalemia & changes in renal function (including acute renal failure). Concomitant use w/ aliskiren. Reduced lithium clearance by diuretics eg, chlorthalidone increasing the risk of lithium toxicity.
Food interactions
[UNSAFE] Azilsartan + Chlorthalidone may cause excessive drowsiness with alcohol.
Use in pregnancy
[CONSULT YOUR DOCTOR] Azilsartan + Chlorthalidone is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Azilsartan + Chlorthalidone is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Renal / hepatic impairment
[CAUTION] Azilsartan + Chlorthalidone should be used with caution in patients with severe kidney disease. Dose adjustment of Azilsartan + Chlorthalidone may be needed. Please consult your doctor. Use of Azilsartan + Chlorthalidone is not recommended in these patients. [CAUTION] Azilsartan + Chlorthalidone should be used with caution in patients with liver disease. Dose adjustment of Azilsartan + Chlorthalidone may be needed. Please consult your doctor. Use of Azilsartan + Chlorthalidone is not recommended in patients with severe liver disease.
Common questions
I am a patient of hypertension Hypertension is clinal condition of high blood pressure. Please see a physician. Some times I had lot of hypertension Hypertension is clinically high blood pressure. Persistent high arterial blood pressure above 120/80 mm HG is termed as pre-hypertension or hypertension, but the point to be emphasized is that this rise in blood pressure is persistent. Transient increase in BP occurs in stress and anxiety and needs to be treated accordingly. I have High Blood Pressure problem. Now I am taking TAZLAC CT 40 tablet in a day. But I am not comfort with this medicine. I want to shift in ayurved. please suggest me Hi Kindly start taking Mukta Vati along with your treatment when you feel better you can consult to your allopathic doctor for reducing your medicine High blood pressure, breathing issues Do yoga and pranayam regularly, take halleezy tablet 2 tablet twice Headache it?s feels like head will blast so much pressure frontal sinusitis is there Take a CT pns What blood reports are required for chest ct scan ? Contrast enhanced scan is done after checking blood urea and creatinine Hypertension blood pressure pro Bp any medicine u taking Does Telsartan CT tablets cause ED Hello Ali. Probably not. There are lot other reason for ED. Erectile problems can be happen to people at any age having issue like stress, fatigue, disturb relationship, anxiety, Alcohal, smoking and medical problems like High BP, Diabetes, obesity etc. My personal advice is lifestyle changes like exercising, losing weight, stopping smoking,curbing alcohol, don't wear tight pants, do pelvic kegal exercise. There are medications but they have side effects so i dont advice first. But i strongly recommend to start healthy life with some antioxidant vitamins and healthy diet. You may take vitamin like DHEA cap, L arginine and herbal ashwagandha capsule. Apply Himcolin gel. Concentrate on Yoga and meditation and also take help from your partner. Use these for couple of months if not improved do few blood tests like thyroid, sugar and testosterone and let me know.