Generic
Beclometasone + Formoterol + Glycopyrronium
4 brands available in the market
At a glance
Beclometasone + Formoterol + Glycopyrronium is an inhaler used for the maintenance treatment of asthma and COPD.
Description
This combination inhaler contains Beclometasone Dipropionate (inhaled corticosteroid), Formoterol Fumarate Dihydrate (long-acting beta-2 agonist), and Glycopyrronium Bromide (long-acting muscarinic antagonist). It works by reducing inflammation and bronchodilation in asthma and COPD.
Indications
- Asthma (maintenance treatment in adults)
- Moderate to severe COPD (maintenance treatment)
Therapeutic class
Respiratory Preparations
Pharmacological class
Combination Inhaler (ICS + LABA + LAMA)
Pharmacology
Beclometasone is an inhaled corticosteroid that reduces inflammation; Formoterol is a long-acting beta-2 agonist that causes bronchodilation; Glycopyrronium is a long-acting muscarinic antagonist that relaxes bronchial smooth muscle.
Mechanism of action
Beclometasone reduces airway inflammation; Formoterol relaxes bronchial muscles to dilate airways; Glycopyrronium blocks muscarinic receptors to cause bronchodilation.
Dosage
Adults (≥18 years): 2 inhalations twice daily (morning and evening, approximately 12 hours apart). Maximum dose: 2 inhalations twice daily.
Administration
Shake the inhaler vigorously (at least 6 times) before use. Breathe out fully, place mouthpiece between teeth, breathe in deeply and slowly while pressing down on the canister. Hold breath for at least 10 seconds. Rinse mouth with water after use (do not swallow).
Missed dose
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.
Side effects
Common: Dysphonia, oral candidiasis, muscle spasms, dry mouth. In asthma, side effects tend to occur in the first 3 months after starting treatment.
Precautions & warnings
Not indicated for acute bronchospasm; may cause paradoxical bronchospasm; caution in cardiac arrhythmias, severe heart disease, hyperthyroidism, diabetes mellitus; rescue inhaler should always be available.
Contraindications
Hypersensitivity to any active substance or excipients.
Drug interactions
Non-cardioselective beta-2 blockers, Quinidine, Disopyramide: May prolong QT interval and increase risk of ventricular arrhythmias.
MAO inhibitors: May precipitate hypertensive reactions.
Halogenated hydrocarbon anesthetics: Increased risk of arrhythmias.
Xanthine derivatives, steroids, diuretics: May potentiate hypokalemia and increase arrhythmia risk.
Food interactions
Can be taken with or without food.
Use in pregnancy
No adequate data in pregnant women; use only if benefit outweighs risk. Avoid during labor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
No adequate information is available regarding use during lactation.
Pediatric use
Safety and effectiveness in pediatric patients have not been established.
Geriatric use
No dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
Caution is advised in patients with severe renal impairment (glycopyrronium is primarily renally excreted).
Overdose effects
Overdose may produce beta-2 agonist or anticholinergic-related symptoms; supportive treatment should be provided.
Storage conditions
Before opening store in refrigerator at 2-8°C (do not freeze); during use, keep below 25°C for maximum 4 months.
Chemical structure
Beclometasone + Formoterol + Glycopyrronium