Beclomethasone Dipropionate

Beclomethasone Dipropionate is a synthetic halogenated corticosteroid with potent anti-inflammatory activity. When given by inhalation, it exerts a potent glucocorticoid anti-inflammatory action within the lungs without the side effects observed when steroids are administered systemically.

Beclomethasone controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes and fibroblasts, reverses capillary permeability, and stabilizes lysosomes at the cellular level to prevent or control inflammation. It reduces airway inflammation and hyperreactivity, helping control asthma symptoms.

Common side effects include pharyngitis, headache, upper respiratory tract infection, rhinitis, dysphonia, and sinusitis.

• Chronic asthma
• Chronic obstructive pulmonary disease (COPD)

Beclomethasone Dipropionate controls the rate of protein synthesis, depresses the migration of polymorphonuclear leukocytes and fibroblasts, reverses capillary permeability, and stabilizes lysosomes at the cellular level to prevent or control inflammation.

When given by inhalation, it acts locally in the lungs, reducing systemic side effects.

Beclomethasone Dipropionate reduces inflammatory cells and mediators in the lungs, decreasing airway inflammation and hyperreactivity. It reduces airway swelling and helps control asthma symptoms.

Adults:

• Chronic asthma management: 100-400 mcg twice daily
• Asthma prophylaxis: 50-200 mcg twice daily; increase to maximum 400 mcg twice daily if needed

Children (5-12 years):

• Chronic asthma management: 100-200 mcg twice daily; maximum 200-400 mcg twice daily
• Asthma prophylaxis: Start with 100 mcg twice daily; may increase to 400 mcg/day in 2-4 divided doses

Children over 12 years: Same as adult dose.

Titrate to the lowest effective dose once symptoms are controlled.

Follow proper inhaler technique:

1. Shake the inhaler well
2. Press the canister while breathing in deeply
3. Hold breath for 10 seconds
4. Rinse mouth after use

Prime the inhaler (2 actuations into the air) before first use and after prolonged idleness (>10 days).

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

• Pharyngitis (5-27%)
• Headache (8-25%)
• Upper respiratory tract infection (5-11%)
• Rhinitis (3-7%)
• Dysphonia (1-4%)
• Sinusitis (3%)
• Oral symptoms (2-3%)
• Nausea (1-2%)
• Increased asthma symptoms (2-4%)

• Instruct patients on proper inhaler technique and the prophylactic nature of therapy
• Use regularly even when asymptomatic
• Not suitable for acute asthma attacks
• May reduce growth velocity in pediatric patients
• Caution during pregnancy and lactation

• Hypersensitivity to beclomethasone dipropionate or any component
• Not recommended for children under 6 years

• CYP3A4 Inhibitors: May increase plasma beclomethasone concentrations
• CYP3A4 Inducers: May decrease plasma beclomethasone concentrations
• Antidiabetic agents: May increase blood glucose concentrations
• NSAIDs: Possible increased risk of GI ulceration; decreased serum salicylate concentrations
• Vaccines and Toxoids: May diminish response; may potentiate replication of live attenuated vaccines

No data is found on interaction with food.

[CONSULT YOUR DOCTOR] There are no adequate well-controlled studies in pregnant women. Animal studies have shown adverse developmental effects. The risk of complications from inadequate asthma control must be balanced against risks from exposure.

[CONSULT YOUR DOCTOR] There are no data on presence in human milk. Other inhaled corticosteroids have been detected in human milk. Consider the benefits of breastfeeding along with the mother's clinical need.

Not recommended for children under 6 years. Children 5-12 years: 100-200 mcg twice daily; over 12 years: adult dose. Intranasal corticosteroids may reduce growth velocity in pediatric patients.

No dose adjustment needed for elderly patients.

Minimal systemic absorption with inhalation, so no dose adjustment needed for renal or hepatic impairment.

Overdose may cause symptoms of hypercorticism. Treatment is symptomatic and supportive.

Store below 30°C, in a dry place, protected from light. Keep out of reach of children.

Beclomethasone Dipropionate (C₂₈H₃₇ClO₇)