Generic
Benzydamine Mouth prep
5 brands available in the market
At a glance
Benzydamine Mouth prep is a pain relieving and anti-inflammatory medicine used to relieve pain, discomfort, and inflammation of the mouth, gums, and throat.
Description
Benzydamine Mouth prep is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, discomfort, and inflammation of the mouth, gums, and throat. It works by inhibiting the synthesis of pro-inflammatory cytokines like TNF-α and IL-1β, and also has a local anesthetic effect by inhibiting the release of inflammatory mediators like substance P.
This medicine is used as a mouthwash or gargle. It should be spat out after use, not swallowed. It can be diluted with water if stinging occurs. Avoid contact with eyes.
Indications
- Mouth/Throat Pain or irritation
- Acute pharyngitis
- Radiation-Associated Mucositis
Therapeutic class
Topical NSAIDs
Pharmacological class
Non-Steroidal Anti-Inflammatory Drug (NSAID)
Pharmacology
Benzydamine Hydrochloride predominantly acts by inhibiting the synthesis of pro inflammatory cytokines like tumour necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) without largely affecting other pro inflammatory cytokines. Moreover, it is capable of a local anaesthetic effect that may be related to its capability for inhibiting the release of inflammatory mediators like substance P.
Mechanism of action
Benzydamine inhibits the synthesis of pro-inflammatory cytokines (TNF-α and IL-1β) to reduce inflammation and provides local pain relief by inhibiting the release of inflammatory mediators like substance P.
Dosage
Mouth/Throat Pain, Acute pharyngitis: Rinse or gargle 15 ml of a 0.15% solution every 1½ to 3 hours until remission of pain (dilute with water if stinging occurs).
Radiation-Associated Mucositis: Gargle or rinse 15 mL in mouth (for 30 seconds, followed by expulsion) 3-4 times per day. Begin treatment 1 day prior to radiation therapy and continue daily during treatment.
Administration
Check the label before use. Take the mouthwash in the quantity as advised by your doctor and put it in your mouth. Swish for 30 seconds to 1 minute and spit it out. Do not swallow. Avoid eating, drinking, or smoking for at least 30 minutes after rinsing.
Missed dose
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
- No common side effects seen
- Mild burning sensation at application site (temporary)
Precautions & warnings
- For mouth rinse or gargle only
- Spit the rinse out after use, do not swallow it
- Should generally be used undiluted; if it stings, dilute with an equal volume of water
- Avoid getting it in your eyes
- Do not use for more than seven days unless otherwise advised by your doctor
- Caution during pregnancy and lactation
Contraindications
- Hypersensitivity to benzydamine hydrochloride or any component
Drug interactions
No significant drug interactions are known.
Food interactions
No food-related restrictions.
Use in pregnancy
[SAFE IF PRESCRIBED] Benzydamine Mouth prep is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Use in lactation
[CONSULT YOUR DOCTOR] Information regarding the use of Benzydamine Mouth prep during breastfeeding is not available. Please consult your doctor.
Pediatric use
Use as directed by a physician for children.
Geriatric use
No dose adjustment needed for elderly patients.
Renal / hepatic impairment
Systemic absorption with topical application is minimal, so no dosage adjustment is needed for renal or hepatic impairment.
Overdose effects
Overuse may cause local irritation. Consult a doctor if symptoms occur.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.
Chemical structure
Benzydamine Hydrochloride