Calcium Dobesilate + Lidocaine + Dexamethasone

Calcium Dobesilate + Lidocaine + Dexamethasone is a rectal ointment used in the ano-rectal region. Calcium Dobesilate acts on the capillary walls by regulating their impaired physiological functions—i.e. increased permeability and decreased resistance and on different signs of inflammation. It also has an antithrombotic activity. Lidocaine hydrochloride, a local anesthetic, contributes to relieve pain. Dexamethasone Acetate, a Corticosteroid for topical use, possesses anti-inflammatory and antipruritic actions.

• Internal and external hemorrhoids
• Anal pruritus
• Anal eczema
• Anitis
• Perianitis
• Acute hemorrhoidal thrombosis
• Anal fissure
• Pre and postoperative treatment in cases of hemorrhoidectomy

Calcium Dobesilate acts on the capillary walls by regulating their impaired physiological functions- i.e. increased permeability and decreased resistance and on different signs of inflammation. It also has an antithrombotic activity. Lidocaine hydrochloride, a local anesthetic, contributes to relieve pain. Dexamethasone Acetate, a Corticosteroid for topical use, possesses anti-inflammatory and antipruritic actions.

Calcium Dobesilate regulates capillary permeability and resistance while reducing inflammation and thrombosis; Lidocaine provides local pain relief; Dexamethasone reduces inflammation and itching.

Apply 2-3 times daily. Apply in the morning and bedtime and if possible after defecation. In case of internal hemorrhoids apply the ointment by the applicator. In cases of external hemorrhoids and anal pruritus, apply a thin layer of the ointment several times a day. The duration of the treatment is generally of some days. The physician must be informed if, after 1 to 2 weeks of treatment the symptomatology has not improved or has worsened.

For internal use: Remove the cap from the tube, pierce the tube membrane by inverting the cap, attach the applicator to the tube, squeeze the tube to fill the applicator and lubricate the tip, insert the applicator gently and to full extend into the anus and squeeze once again to force the required amount of ointment into the anal canal, remove the applicator after application and discard it. Try not to have defecation for a couple of hours after an internal application.
For external use: Squeeze the tube and apply a small amount to the finger, apply the ointment around the outside of the anus with a finger, wash hands thoroughly with warm water and soap after each application.

If you miss a dose, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Rare Side Effects:

• Modifications of intestinal transit
• Temporary burning sensation
• Local pain
• Hypersensitivity reactions with skin reactions and/or fever

• In case of renal insufficiency, do not use for longer periods.
• Avoid long-lasting treatments.
• Discontinue treatment if allergic reactions occur.

• Hypersensitivity towards the components of this preparation.

No adequate information on drug interactions is available.

Can be used with or without food. No specific food interactions have been identified.

Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Calcium Dobesilate is excreted in maternal milk in low amounts. Lidocaine and Dexamethasone are excreted in maternal milk. A decision should be made between discontinuing treatment or breastfeeding.

Safety and effectiveness in pediatric populations have not been established.

No specific dosage adjustment is necessary for elderly patients. However, caution should be exercised.

In case of renal insufficiency, do not use for longer periods.

No overdosage information is available.

Store below 30°C, protected from heat. Keep out of reach of children.

Calcium Dobesilate + Lidocaine + Dexamethasone