Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops

Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops is a prescription medicine used for the treatment of acute bacterial ear infections. Chloramphenicol is an antibiotic that stops bacterial growth by inhibiting bacterial protein synthesis. Lidocaine is a local anesthetic that provides pain relief. This combination is effective in treating ear infections and helps reduce pain. This medicine is for use in the ear only and should be used as directed by a doctor.

• Acute bacterial ear infections
• Otitis externa
• Aural otitis

Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae. Lidocaine is an amide type local anesthetic. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.

Chloramphenicol stops bacterial growth by inhibiting bacterial protein synthesis. Lidocaine stabilizes the neuronal membrane and blocks pain signal transmission, providing pain relief.

Adult Dose (Otic): Otitis externa/Aural otitis: Instill 2-3 drops into the ear 2-3 times daily.

This medicine is for use in the ear only. Use in the dose and duration as advised by your doctor. Shake well before use.

If you miss a dose of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side Effects:

• Ototoxicity (hearing impairment)
• Local irritation
• Allergic reactions

• Avoid prolonged use.
• Discontinue immediately if local hypersensitivity reactions occur.
• Do not use if you have a perforated ear drum.
• Caution required during pregnancy and lactation.

• History of hypersensitivity or toxic reaction to the drug
• Perforated ear drum
• Herpes simplex and other viral conditions of the ear
• Mycosis (fungal infections)

Decreased effects of iron and vitamin B12 in anemic patients. Phenobarbitone and rifampin reduce efficacy of chloramphenicol. Impairs the action of oral contraceptives. Increases the effect of oral anticoagulants, oral hypoglycemic agents, phenytoin. Avoid concomitant administration with drugs that depress bone marrow function. May increase serum levels with cimetidine and propranolol. Increased risk of cardiac depression with beta-blockers and other antiarrhythmics. Additive cardiac effects with IV phenytoin. Hypokalaemia caused by acetazolamide, loop diuretics and thiazides may antagonise effect of lidocaine. Dose requirements may be increased with long-term use of phenytoin and other enzyme-inducers.

No food interactions found or established.

Limited information is available regarding the use of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops during pregnancy. Please consult your doctor.

Limited information is available regarding the use of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops during breastfeeding. Please consult your doctor.

Limited information is available regarding safety and efficacy in pediatric patients. Use as advised by a physician.

Limited information is available regarding dose adjustment for elderly patients.

No information is available on use in kidney or liver problems.

Information on overdosage is not available. Consult a physician if overdose is suspected.

Keep in a cool and dry place, away from light & keep out of the reach of children.

Chloramphenicol + Lidocaine Hydrochloride