Clofazimine

Clofazimine belongs to a class of drugs known as antileprotic medicines. It is used in combination with other medicines for the treatment of leprosy. It works by stopping the growth of disease causing organisms in the body. Clofazimine should be used in the dose and duration as advised by your doctor. It should be taken with food, preferably at a fixed time. Avoid skipping any doses and finish the full course of treatment even if you feel better. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. Some people may experience nausea, stomach upset and vomiting as the side effects of this medicine. It may also discolor your skin, urine, saliva, tears and other body fluids. This is normally temporary and resolves once the treatment is completed. Please consult your doctor if these side effects bother you or persist for a longer duration. Clofazimine stops the growth of bacteria in the body.

• Leprosy

Clofazamine inhibits mycobacterial growth by binding preferentially to mycobacterial DNA. It also has some anti-inflammatory activity.

Adult Dose: Dapsone-sensitive multibacillary leprosy 50 mg PO qDay in combination with dapsone 100 mg/day and rifampicin 600 mg/day Administer for at least 2 years and continued, if possible, until negative skin smears are obtained At this time, monotherapy with an appropriate antileprosy drug can be instituted Dapsone-resistant leprosy 100 mg PO qDay in combination with 1 or more other antileprosy drugs for 3 years, followed by monotherapy with 100 mg of clofazimine daily

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Clofazimine is to be taken with food.

Common: • Vomiting • Nausea • Diarrhea • Loss of appetite • Rash • Itching • Skin peeling • Skin discoloration • Eye discoloration

[UNSAFE] Clofazimine may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Clofazimine is used in combination with other medicines for the treatment of leprosy. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Take it with or just after meal. Take it as per the dose and duration prescribed by your doctor. It may discolour your skin, urine, saliva, tears and other body fluids. This is normal and not harmful.

Hypersensitivity. Lactation.

Dapsone Concomitant use of dapsone and clofazimine does not have a clinically important effect on dapsone pharmacokinetics. Some evidence suggests dapsone may decrease or nullify some anti-inflammatory effects of clofazimine and theoretically might adversely affect clofazimine’s efficacy in patients with ENL reactions; several borderline leprosy and lepromatous leprosy patients with severe, recurrent ENL reactions reportedly required higher clofazimine dosage to control these reactions when dapsone therapy was given concomitantly than when clofazimine was given alone. Isoniazid Possible increased clofazimine plasma and urine concentrations and decreased clofazimine skin concentrations. Rifampin Although one study indicated that concomitant use of clofazimine in leprosy patients receiving rifampin alone or in conjunction with dapsone may decrease plasma concentrations and AUC of rifampin, concomitant use of clofazimine in another study in lepromatous leprosy patients receiving dapsone (100 mg daily) and rifampin (600 mg daily) did not affect rifampin pharmacokinetics.

[SAFE] Consuming alcohol with Clofazimine does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Clofazimine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Clofazimine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Clofazimine is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Clofazimine may not be needed in these patients. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Clofazimine in patients with liver disease. Please consult your doctor.

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