Clonidine Hydrochloride

Clonidine Hydrochloride is a medicine used in the treatment of hypertension (high blood pressure). It lowers the blood pressure by relaxing the blood vessels. Lowering the blood pressure helps to prevent future stroke and heart attack. Clonidine Hydrochloride is also used to prevent migraine and hot flushes in women during menopause. This medicine can be taken with or without food but it is better to take it at the same time every day. You should always take this medicine as advised by the doctor and should never stop it without consulting the doctor. Most people with high blood pressure do not feel ill, but if you stop taking this medicine, your condition could get worse. This may lead to your blood pressure rising up again and increase your risk of heart disease and stroke. You should monitor your blood pressure regularly while taking this medicine. Common side effects of this medicine include dizziness, headache, nausea, fatigue, dry mouth, and constipation. Consult your doctor if these side effects bother you. Before taking this medicine, it is better to let your doctor know if you are suffering from any kidney or liver disease. Also, pregnant women and breastfeeding mothers should consult a doctor before taking it. Clonidine Hydrochloride is an alpha-2 agonist. It works by relaxing blood vessels which makes the heart more efficient at pumping blood around the body.

• Hypertension (high blood pressure)

Clonidine stimulates alpha-2 receptors in brain stem which results in reduced sympathetic outflow from the CNS and a decrease in peripheral resistance leading to reduced BP and pulse rate. It does not alter normal haemodynamic response to exercise at recommended dosages.

Adult Dose: Oral Hypertension Adult: Initially, 50-100 mcg tid, increased every 2nd or 3rd day according to response. Maintenance: 300-1,200 mcg daily, some may require >1,800 mcg daily. Max: 2,400 mcg daily. Prophylaxis of migraine; Menopausal flushing Adult: 50 mcg bid, increased to 75 mcg bid if no remission after 2 wk. Child Dose: <12 years old: Safety and efficacy not established Renal Dose: Renal impairment: Supplemental doses after haemodialysis are not necessary. CrCl (ml/min) <10 50-75% of usual dose.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Clonidine Hydrochloride may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Clonidine Hydrochloride, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Dizziness • Sleepiness • Dryness in mouth • Constipation

[UNSAFE] Clonidine Hydrochloride may cause blurring of your vision for a short time just after its use. Do not drive until your vision is clear. Clonidine Hydrochloride may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. It may cause you to feel lightheaded especially when you stand up (orthostatic hypotension). Rise slowly if you have been sitting or lying down. It may cause dryness of eyes. Take caution while using contact lenses. Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.

Hypersensitivity. Disorders of cardiac pacemaker activity and conduction. Pregnancy and lactation.

Hypotensive action may be potentiated by diuretics and vasodilators. Effects of clonidine antagonised by TCAs and centrally-acting alpha-blockers. May enhance toxicity due to digitalis, lithium. May antagonise oral hypoglycaemics. Potentially Fatal: Hypnosedatives, antihistamines and alcohol may cause excessive drowsiness in patients on clonidine. Withdrawal of clonidine in patients receiving noncardioselective ?-blockers may result in rebound BP. Acute severe hypotension following concomitant administration of clonidine and chlorpromazine or haloperidol.

[UNSAFE] It is unsafe to consume alcohol with Clonidine Hydrochloride.

[CONSULT YOUR DOCTOR] Clonidine Hydrochloride may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Clonidine Hydrochloride is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Clonidine Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Clonidine Hydrochloride may be needed. Please consult your doctor. Regular monitoring of blood pressure is advisable for dose adjustment. [CAUTION] Clonidine Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Clonidine Hydrochloride may be needed. Please consult your doctor.

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