Clotrimazole 1% Ear prep

Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms. Clotrimazole inhibits ergosterol synthesis, resulting in abnormal cellular permeability. This inhibits fungal growth. It has also antibacterial activity. Clotrimazole ear drop is used for the treatment of fungal ear infections.

• Fungal otitis externa

Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells.

Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.

Adult Dose (Ear Drops): Apply 2-3 drops in the affected ear two or three times daily. Treatment should be continued for at least two weeks after the disappearance of all signs of infection to prevent re-infection.

Instill 2-3 drops in the affected ear two or three times daily. Shake well before use. Not for ophthalmic use.

If you miss a dose of Clotrimazole 1% Ear prep, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common Side Effects (infrequent):

• Erythema (redness)
• Stinging
• Edema (swelling)
• Pruritus (itching)
• General irritation

• For ear use only. Not for ophthalmic use.
• If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy.
• Caution during pregnancy and lactation.
• Not recommended in children under 3 years.

• Hypersensitivity.

Antagonism with polyene antibiotics. There have been reports of a heat reaction when this medication is used concomitantly with Sofradex drops in the ear.

No food interactions have been found or established.

Systemic absorption of clotrimazole following topical application is marginal, so there should be low risk during pregnancy. However, consult your doctor before use.

Systemic absorption of clotrimazole following topical application is marginal, so there should be no risk for the infant during lactation. However, consult your doctor before use.

Not recommended in children under 3 years.

Limited information is available regarding dose adjustment for elderly patients.

For topical/ear use, no dose adjustment is required in renal or hepatic impairment.

In case of accidental oral ingestion, supportive measures should be taken.

Protect from light, store in cool & dry place. Protect from freezing. Do not use more than 4 weeks after opening. Keep out of reach of children.

Clotrimazole 1%