Generic
D-chiro-inositol
18 brands available in the market
At a glance
D-chiro-inositol is a natural compound used for the treatment and prevention of Polycystic Ovary Syndrome (PCOS), anovulation, menstrual disorders, and hyperandrogenism-related conditions.
Description
D-chiro-inositol is extracted by a patented process from Carob (Ceratonia siliqua) pod that is mostly found in Southern Europe. Deficiency of D-chiro-inositol in peripheral tissue causes insulin resistance that leads to hyperandrogenism in ovaries which results in polycystic ovary syndrome (PCOS). D-chiro-inositol helps to regulate the balance between androgen and estrogen by decreasing luteinizing hormone and serum testosterone level. It improves glucose tolerance and reduces circulating insulin. It reduces oxidative stress on follicle and decreases total cholesterol and triglyceride levels.
Indications
- Polycystic Ovary Syndrome (PCOS)
- Anovulation
- Menstrual disorders such as amenorrhea
- Hyperandrogenism complaints such as hirsutism, alopecia, acanthosis nigricans, acne
- Ovarian hyperthecosis
Therapeutic class
Trophic Hormones & Related Synthetic Drugs
Pharmacological class
Inositol Derivative (Natural Compound)
Pharmacology
D-chiro-inositol is extracted by a patented process from Carob (Ceratonia siliqua) pod that is mostly found in Southern Europe. Deficiency of D-chiro-inositol in peripheral tissue causes insulin resistance that leads to hyperandrogenism in ovaries which results in polycystic ovary syndrome (PCOS). D-chiro-inositol helps to regulate the balance between androgen and estrogen by decreasing luteinizing hormone and serum testosterone level. It improves glucose tolerance and reduces circulating insulin. It reduces oxidative stress on follicle and decreases total cholesterol and triglyceride levels.
Mechanism of action
D-chiro-inositol regulates the androgen-estrogen balance by decreasing luteinizing hormone and serum testosterone levels, improves insulin sensitivity, and reduces oxidative stress to improve PCOS symptoms.
Dosage
Adult: 1-2 capsules orally daily or as advised by the physician. Duration of treatment should be minimum 2 months.
Administration
Can be taken with or without food. Take in the dose and duration as advised by your doctor.
Missed dose
If you miss a dose of D-chiro-inositol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.
Side effects
Well tolerated in recommended dose. No significant side effects are usually reported.
Precautions & warnings
- Considered safe for use during pregnancy and lactation.
- Use as directed by your physician.
Contraindications
- Hypersensitivity to D-chiro-inositol.
Drug interactions
Digoxin: Concurrent use may result in increased digoxin toxicity.
Food interactions
Can be taken with or without food.
Use in pregnancy
Several human studies have been conducted with inositol and no clinically relevant adverse effects have been found. Considered safe during pregnancy.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Use in lactation
Several human studies have been conducted with inositol and no clinically relevant adverse effects have been found. Considered safe during lactation.
Pediatric use
Safety and effectiveness in pediatric populations have not been established.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
No adequate information is available regarding the use in patients with kidney or liver problems. Please consult your doctor.
Overdose effects
No adequate information on overdose is available. If you take more than the recommended dose, consult your doctor.
Storage conditions
Store at temperature below 30°C, protect from light & moisture. Keep out of reach of children.
Chemical structure
D-chiro-inositol