Desloratadine

Desloratadine, the major active metabolite of Loratadine, is a non-sedating, long acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Desloratadine also inhibits histamine release from human mast cell.

• Seasonal and perennial allergic rhinitis (sneezing, nasal discharge, itching, congestion, ocular itching, tearing, redness)
• Chronic idiopathic urticaria (hives, itching)

Desloratadine, the major active metabolite of Loratadine, is a non-sedating, long acting tricyclic histamine antagonist with selective H1-receptor histamine antagonist activity. Desloratadine also inhibits histamine release from human mast cell.

Desloratadine blocks histamine action at peripheral H1-receptors, relieving allergy symptoms such as itching, swelling, and rashes, and reduces pro-inflammatory mediator release from mast cells.

Adults & ≥12 years: 5 mg once daily.
Children 6-11 years: 2.5 mg (5 ml syrup) once daily.
Children 1-5 years: 1.25 mg (2.5 ml syrup) once daily.
Children 6-11 months: 1 mg (2 ml drops) once daily.
Hepatic or renal impairment: 5 mg every other day.

May be taken with or without food, but it is better to take it at a fixed time. Swallow the tablet whole, do not chew, crush or break.

If you miss a dose of Desloratadine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common: Sleepiness, headache, nausea, fatigue, dizziness, pharyngitis, dyspepsia, myalgia.

Caution while driving (dizziness, sleepiness may occur). Avoid alcohol (may cause excessive drowsiness). Stop at least 3 days before allergy testing. Caution in liver and kidney disease.

Hypersensitivity.

Drugs affecting hepatic microsomal enzymes (azithromycin, cimetidine, erythromycin, fluoxetine, ketoconazole): May increase plasma concentrations.

It is unsafe to consume alcohol with Desloratadine (may cause excessive drowsiness).

Pregnancy Category C. The safe use of Desloratadine during pregnancy has not been established. Should be used only if clearly indicated.

Desloratadine passes into breast milk. Because of its low milk levels and lack of sleepiness, use would not be expected to cause adverse effects in breastfed babies.

Safety and effectiveness in children below 6 months have not been established.

No specific dosage adjustment is necessary for elderly patients.

Renal impairment: Use with caution. Dose adjustment may be needed.
Hepatic impairment: Use with caution. Dose adjustment may be needed.

No clinically relevant adverse effects have been reported.

Store below 30°C in a cool & dry place, protected from light. Keep out of reach of children.

Desloratadine