Dextromethorphan + Phenylephrine + Triprolidine

This preparation is a mixture of antitussive, decongestant and antihistamine agent. Dextromethorphan is a safe, effective, non-narcotic antitussive agent which has a central action on the cough centre in the medulla. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passage. Triprolidine is a potent competitive histamine H1-receptor antagonist which may cause drowsiness.

• Cough due to minor throat or bronchial irritation
• Runny nose, sneezing, itching of nose or throat
• Itchy, watery eyes
• Nasal congestion

Dextromethorphan is a safe, effective, non-narcotic antitussive agent which has a central action on the cough centre in the medulla. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passage. Triprolidine is a potent competitive histamine H1-receptor antagonist which may cause drowsiness.

Dextromethorphan acts on the cough centre to suppress cough; Phenylephrine constricts nasal blood vessels to reduce congestion; Triprolidine blocks histamine receptors to relieve allergy symptoms.

Adults & Children (≥12 years): 1 teaspoonful (5 ml) every 4 hours.
Children (6-12 years): ½ teaspoonful (2.5 ml) every 4 hours.
Children (2-6 years): Use with caution and under medical advice.
Children under 2 years: Do not use.

Take with or without food (take with food if stomach upset occurs). Measure liquid doses carefully.

If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

MAOIs (isocarboxazid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, selegiline, tranylcypromine): Serious (possibly fatal) interaction.
Topical antihistamines, antispasmodics, beta-blockers, Parkinson's drugs, guanethidine, inhaled anesthetics, methyldopa, reserpine, scopolamine, tricyclic antidepressants, anti-seizure drugs, sleep/anxiety medicines, muscle relaxants, narcotic pain relievers, psychiatric medicines: Caution required.

Take with or without food. Avoid alcohol.

Liver disease, asthmatic patients; patients taking MAOIs or within 2 weeks of stopping; hypersensitivity; acute asthma attacks; severe hypertension or severe coronary artery disease.

Common: Drowsiness, dizziness, constipation, GI discomfort.
Other: Transient hypertension, dry mouth, restlessness, palpitations, allergic reactions (rash), chest tightness, thickening of bronchial secretions, toxic psychosis, blood dyscrasia.

Use during pregnancy is best avoided.

Use during lactation is best avoided.

May cause drowsiness; do not drive or operate machinery. Avoid alcohol. Caution in epilepsy, prostatic hypertrophy, glaucoma, liver disease, hypertension, heart disease, diabetes, hyperthyroidism, stenosing peptic ulcer, pyloro-duodenal obstruction, bladder neck obstruction. Consult doctor if no improvement within 1 week or with high fever.

Do not use in children under 2 years. Use with caution in children 2-6 years under medical advice.

No specific dosage adjustment is necessary for elderly patients.

Caution in epilepsy, prostatic hypertrophy, glaucoma, liver disease, hypertension, heart disease, diabetes, hyperthyroidism, stenosing peptic ulcer, pyloro-duodenal obstruction, bladder neck obstruction.

Overdose may cause respiratory depression, paranoid psychosis, delusions, hallucinations, convulsions; phenylephrine overdose may cause hypertension and reflex bradycardia. Hospital admission is strongly advised.

Store in a cool & dry place, protected from light. Keep out of reach of children.

Dextromethorphan + Phenylephrine + Triprolidine