Generic
Dextromethorphan + Pseudoephedrine + Triprolidine
22 brands available in the market
At a glance
Dextromethorphan + Pseudoephedrine + Triprolidine is a combination medicine used for the treatment of flu, colds, dry cough, and nasal congestion.
Description
Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine, an alpha- and beta-adrenergic receptor agonist, mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.
Indications
- Flu and colds
- Dry cough and non-productive cough
- Nasal congestion
Therapeutic class
Combined cough suppressants
Pharmacological class
Antitussive + Decongestant + Antihistamine
Pharmacology
Triprolidine is a potent competitive histamine H1-receptor antagonist with mild sedating and antimuscarinic properties. Pseudoephedrine mediates vasoconstriction via direct stimulation of alpha-adrenergic receptors. Dextromethorphan is a centrally acting cough suppressant which acts on the cough centre in the medulla.
Mechanism of action
Dextromethorphan acts on the cough centre to suppress cough; Pseudoephedrine constricts nasal blood vessels; Triprolidine blocks histamine receptors to relieve allergy symptoms.
Dosage
Adults: 2 teaspoonful three times a day.
Children (>12 years): 2 teaspoonful three times a day.
Children (6-12 years): 1 teaspoonful three times a day.
Children (2-6 years): ½ teaspoonful three times a day.
Administration
Take with or without food.
Missed dose
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.
Side effects
Common: Dizziness, GI disturbances.
Precautions & warnings
Caution in 3rd trimester of pregnancy; atopic children; children <1 year; sedated or debilitated patients; patients confined to supine position; history of asthma; moderate to severe renal impairment; liver disease.
Contraindications
Patients at risk of respiratory failure; during acute attack; patients receiving MAOIs or within 2 weeks of stopping; persistent or chronic cough.
Drug interactions
Dextromethorphan: TCAs, antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol.
Potentially Fatal: Memantine, moclobemide.
Triprolidine + Pseudoephedrine: Increased BP with sympathomimetics; reduced hypotensive effects of methyldopa and adrenergic blockers; increased side effects with atomoxetine.
Potentially Fatal: Hypertensive crisis with furazolidine; hypertensive crisis with MAOIs; increased psychosis risk with bromocriptine.
Food interactions
Take with or without food.
Use in pregnancy
Avoid use during the 3rd trimester of pregnancy.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Use in lactation
No adequate information is available regarding use during lactation.
Pediatric use
Do not use in children under 1 year of age.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
Caution in moderate to severe renal impairment and liver disease.
Overdose effects
No adequate information on overdose is available.
Storage conditions
Store in a cool & dry place, protected from light.
Chemical structure
Dextromethorphan + Pseudoephedrine + Triprolidine