Generic
Diabasic Sodium Phosphate + Monobasic Sodium Phosphate
1 brands available in the market
At a glance
Diabasic Sodium Phosphate + Monobasic Sodium Phosphate is a saline laxative and bowel cleansing solution used for constipation and colon cleansing.
Description
Sodium phosphate draws water into the lumen of the gut where it causes osmotic effect; causes abdominal distention and promotes peristalsis and evacuation of the bowel. It acts as a saline cathartic.
Indications
- Relief of occasional constipation
- Bowel cleansing (before surgery, x-ray, or endoscopic examination)
- Preparation for colonoscopy
Therapeutic class
Enema & bowel cleansing solution
Pharmacological class
Saline Laxative
Pharmacology
Sodium phosphate is a saline cathartic that draws water into the intestinal lumen, creates osmotic effect, causes abdominal distention, and promotes peristalsis and bowel evacuation.
Mechanism of action
Diabasic Sodium Phosphate + Monobasic Sodium Phosphate draws water into the bowels, softens stool, and promotes bowel movement.
Dosage
Adult (Oral Tablets): Evening before colonoscopy: 4 tablets with 8 oz clear liquid every 15 min (total 20 tablets); Day of procedure: 4 tablets with 8 oz clear liquid every 15 min (total 12 tablets).
Adult (Rectal Enema): 1 bottle PR; not to exceed 1 administration/24 hr.
Children (2-4 years): Half bottle of pediatric enema (~30 mL) PR.
Children (5-11 years): 1 bottle of pediatric enema (59 mL) PR.
Children (≥12 years): Same as adults.
Administration
Remove protective shield from enema tip, gently insert tip into rectum (pointing toward navel). Squeeze bottle until nearly all liquid is gone. Maintain position for 1-5 minutes (do not retain for more than 10 minutes).
Missed dose
If you miss a dose, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose.
Side effects
Common: Nausea, vomiting, abdominal pain, abdominal distension, diarrhea, gastrointestinal pain.
Serious: Dehydration, hyperphosphatemia, hypocalcemia, hypokalemia, hypernatremia, metabolic acidosis, hypersensitivity, pruritus.
Precautions & warnings
Use with caution in patients with renal impairment, cirrhosis, cardiac failure, or with edema-causing medications. Should not be used with sodium retaining medications. Caution in patients receiving corticosteroids or corticotropin. Caution during lactation.
Contraindications
Diseases where high sodium, high phosphorus or low calcium levels may be encountered; allergy/hypersensitivity; acute phosphate nephropathy; GI obstruction; gastric bypass surgery; bowel perforation; toxic colitis; toxic megacolon; children under 2 years.
Drug interactions
Calcium channel blockers, diuretics, lithium: May affect electrolyte levels (hyperphosphatemia, hypocalcemia, hypokalemia, hypernatremic dehydration, acidosis).
Lithium: May cause fall in serum lithium levels.
Do not use with other sodium phosphate preparations concomitantly.
Food interactions
Drink large amounts of clear liquids to prevent dehydration.
Use in pregnancy
Pregnancy Category C. No adequate data available; should only be used as directed by a physician.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Sodium phosphate may pass into breast milk; it is advised to express and discard breast milk for at least 24 hours after receiving this medicine.
Pediatric use
Do not use in children under 2 years of age.
Geriatric use
Use with caution in elderly patients.
Renal / hepatic impairment
Use with caution in patients with renal impairment.
Overdose effects
Overdose may cause dehydration and electrolyte imbalance; rehydration and medical intervention required.
Storage conditions
Store below 25°C. Protect from light. Do not refrigerate. Keep out of reach of children.
Chemical structure
Diabasic Sodium Phosphate + Monobasic Sodium Phosphate