Eptifibatide

Eptifibatide is a blood thinner which prevents formation of harmful blood clots. It is used in the treatment of a heart attack and also prevents the clotting of blood in the heart during an angioplasty (procedure to improve blood flow to the heart). Eptifibatide is administered under the supervision of a doctor. Your doctor will decide the dose and duration of the medicine for you. You should continue all your other medicines that are advised by the doctor for your long-term treatment even after this injection. Use of this medicine may cause low blood platelets and increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. It may also cause low blood pressure as a side effect. Your doctor will explain the benefits and risks associated with this medicine before it is administered. This medicine is used with caution for some people. Before taking it, you must inform the doctor if you are suffering from any bleeding disorder, kidney or liver disease. Also, let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Eptifibatide is an antiplatelet medication. It works by preventing the platelets from sticking together, thereby decreasing the formation of harmful blood clots.

• Heart attack

Eptifibatide is a cyclic heptapeptide which blocks the platelet glycoprotein IIb/IIIa receptor thus preventing platelet aggregation and thrombosis.

Adult Dose: Intravenous Unstable angina Adult: 180 mcg/kg via IV inj followed by 2 mcg/kg per minute by IV infusion for up to 72 hr. If percutaneous coronary intervention (PCI) is performed during therapy, infusion should be continued for 18-24 hr after procedure, up to a maximum total duration of 96 hr of therapy. Angioplasty Adult: Initially, 180 mcg/kg via IV inj, to be given immediately before procedure, followed by 2 mcg/kg/minute via IV infusion. A second dose of 180 mcg/kg via IV inj should be given 10 minutes after the 1st dose. Continue infusion until hospital discharge or for up to 18-24 hr (minimum treatment duration: 12 hr). Renal Dose: Renal Impairment (CrCl <50 mL/min) ACS: 180 mcg/kg IV, THEN continuous infusion 1 mcg/kg/min PCI: 180 mcg/kg IV, THEN continuous infusion 1 mcg/kg/min with another 180 mcg/kg IV bolus 10 minutes after 1st one Hemodialysis: Safety and using during hemodialysis not established

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Eptifibatide, please consult your doctor.

Common: • Bleeding • Decreased blood pressure

[NOT RELEVANT] Not relevant, as Eptifibatide is intended for use in hospitalised patients. It is usually given by your nurse or doctor as an infusion (drip) into a vein. It increases your risk of bleeding. Be careful while shaving, cutting fingernails or toenails or using sharp objects. Notify your doctor if you see blood in your vomit, urine or stool (black, tarry stools or bright red blood).

Active bleeding, increased risk of haemorrhage including hemorrhagic disorders, cerebrovascular disorders, history of stroke, uncontrolled hypertension, severe trauma, severe renal impairment, recent major surgery. Lactation.

Increased risk of bleeding w/ heparin, other anticoagulants, antiplatelet & thrombolytic agents.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Eptifibatide. Please consult your doctor.

[SAFE IF PRESCRIBED] Eptifibatide is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[CAUTION] Eptifibatide should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.

[CAUTION] Eptifibatide should be used with caution in patients with kidney disease. Dose adjustment of Eptifibatide may be needed. Please consult your doctor. Use of Eptifibatide is not recommended in patients with severe kidney disease. [CONSULT YOUR DOCTOR] There is limited information available on the use of Eptifibatide in patients with liver disease. Please consult your doctor. Use of Eptifibatide is not recommended in patients with severe liver disease.

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