Escitalopram

Escitalopram is widely prescribed to treat depression and other mental health conditions like anxiety, panic disorder, and obsessive-compulsive disorder. It is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). Escitalopram helps many people to recover from depression by improving their mood and relieving anxiety and tension. It can be taken with or without food. The dose and how often you need it will be decided by your doctor so that you get the right amount to control your symptoms. Your doctor may start you on a lower dose and increase it gradually. Do not change the dose or stop taking it without talking to your doctor, even if you feel well. Doing so may make your condition worse or you may suffer from unpleasant withdrawal symptoms (anxiety, restlessness, palpitations, dizziness, sleep disturbances, etc). To get the most benefit, take this medicine regularly at the same time each day. Your doctor may advise you to take it in the morning if you have trouble sleeping. It may take a few weeks before you start feeling better. Let your doctor know if you do not see any improvement even after 4 weeks. Some common side effects of this medicine include nausea, fatigue, increased sweating, insomnia (difficulty in sleeping), decreased sexual drive, delayed ejaculation, and women may experience difficulties achieving orgasm. Some people may experience sleepiness after taking this medicine. Let your doctor know straight away if you develop any sudden worsening of mood or any thoughts about harming yourself. Before taking Escitalopram, you should tell your doctor if you have epilepsy (seizure disorder or fits), diabetes, liver or kidney disease, any heart problems, or are currently taking medicines for depression known as MAO inhibitors. These may affect your treatment. Please tell your doctor about all the medicines you are taking to make sure you are safe. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It works by increasing the levels of serotonin, a chemical messenger in the brain. This improves mood and physical symptoms of depression and also relieves symptoms of anxiety, panic attacks and obsessive-compulsive disorders.

• Depression • Anxiety • Panic disorder • Obsessive-compulsive disorder

Escitalopram selectively inhibits CNS neuronal re-uptake of serotonin (5-HT) and potentiates serotonergic activity. It has minimal effects on norepinephrine and dopamine neuronal re-uptake.

Adult Dose: Oral Anxiety; Depression; Obsessive compulsive disorder Adult: 10 mg once daily, increased after at least a wk if needed. Max: 20 mg once daily. Panic disorder with or without agoraphobia Adult: Initially, 5 mg once daily, increased after a wk to 10 mg once daily. Max: 20 mg daily. Elderly: Half the adult dose. Hepatic impairment: Mild to moderate: Initially, 5 mg daily, increased to 10 mg daily after 2 wk if needed. Severe: More careful dose titration needed. Child Dose: Major Depressive Disorder 12 years: 10 mg PO qDay; may increase dose after at least 3 weeks; not to exceed 20 mg/day

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Escitalopram may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Escitalopram, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Anorgasmia (decreased orgasm) in women • Decreased libido • Delayed ejaculation • Fatigue • Increased sweating • Insomnia (difficulty in sleeping) • Nausea • Sleepiness

[UNSAFE] Escitalopram may cause side effects which could affect your ability to drive. Take it in the morning since it can keep you awake if taken late at night. Talk to your doctor if you notice sudden mood changes or develop suicidal thoughts. It has a lower chance of causing sexual dysfunction than other similar medications. The addiction or dependence potential of Escitalopram is very less. Do not stop taking the medication suddenly without talking to your doctor first. Some people can develop dizziness or drowsiness after taking this medicine. Do not drive or do anything that requires mental focus until you know how this medicine affects you

Concomitant use with or within 2 wk of MAOI withdrawal.

Increased risk of bleeding when used with aspirin, NSAIDs or drugs that affect coagulation. Serum levels may be reduced by CYP2C19 inducers (e.g. carbamazepine, rifampin, phenytoin) or CYP3A4 inducers (e.g. nafcillin, nevirapine). Serum levels may also be increased by CYP2C19 inhibitors (e.g. fluconazole, fluvoxamine, omeprazole) or CYP3A4 inhibitors (e.g. azole antifungals, clarithromycin). May increase serum levels of desipramine or metoprolol. Increased risk of serotonin syndrome when used with linezolid or sibutramine. Escitalopram may enhance the sedative effects of alcohol. Potentially Fatal: Concomitant administration with MAOIs may lead to serious or fatal reactions; should not be started until at least 2 wk after stopping escitalopram or vice versa. Moclobemide may increase the risk of serotonin syndrome.

[UNSAFE] It is unsafe to consume alcohol with Escitalopram.

[CONSULT YOUR DOCTOR] Escitalopram may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Escitalopram is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Escitalopram should be used with caution in patients with severe kidney disease. Dose adjustment of Escitalopram may be needed. Please consult your doctor. [CAUTION] Escitalopram should be used with caution in patients with liver disease. Dose adjustment of Escitalopram may be needed. Please consult your doctor.

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