Esomeprazole Magnesium Trihydrate

Esomeprazole Magnesium Trihydrate is a medicine which reduces the amount of acid produced in your stomach. It is used to treat heartburn, acid reflux and problems in your food pipe. It is also used to prevent and treat stomach ulcers. You should take Esomeprazole Magnesium Trihydrate as your doctor advises. The dose will depend on what you are being treated for, but it should be the lowest dose for the shortest amount of time needed to treat your condition. Normally it should be swallowed whole about an hour before a meal and at the same time each day. It may take up to a few weeks to work properly but your doctor will tell you how long you need to be taking it for. You should keep on taking it as prescribed even if your symptoms disappear quickly. If you are taking this medicine for a long time, your doctor may carry out regular tests to check your levels of magnesium which can fall with this medicine. Common side effects include headache, constipation or diarrhoea, stomach pain and feeling or being sick. These tend to be mild but talk to your doctor if they bother you or do not go away. The risk of side effects may increase the longer you take this medicine. Serious side effects are rare, but some need immediate medical attention. Ask your doctor what these are. You may be more likely to have a broken bone if you take it for a long time. It is best to avoid foods that seem to make your symptoms worse, such as rich, spicy and fatty foods. It also helps to cut down on caffeinated drinks, such as tea, coffee and cola, as well as alcohol. Esomeprazole Magnesium Trihydrate is not suitable for some people. Before taking this medicine, you need to tell your doctor if you have severe liver problems, are taking medicines for HIV, have had an allergic reaction to similar medicines in the past or have osteoporosis. Alcohol does not interfere with the way Esomeprazole Magnesium Trihydrate works. However, drinking alcohol makes your stomach produce more acid than normal. This medicine can make you feel dizzy, sleepy, or affect your vision. If this happens, do not drive, cycle or use machinery or tools until you feel better. It is not usually recommended during pregnancy and breastfeeding. Esomeprazole Magnesium Trihydrate is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

• Gastroesophageal reflux disease (Acid reflux) • Peptic ulcer disease

Esomeprazole is a PPI that suppresses gastric acid secretion by inhibiting H+/K+ ATPase in the gastric parietal cell. It is the S-isomer of omeprazole.

Adult Dose: GERD Without Erosive Esophagitis 20 mg PO qDay for 4 weeks; consider an additional 4 weeks of treatment if symptoms do not resolve completely in the first 4 weeks GERD With Erosive Esophagitis 20-40 mg PO qDay for 4-8 weeks If oral therapy inappropriate or not possible: 20-40 mg qDay IV up to 10 days; switch to PO once patient able to swallow Maintenance: 20 mg PO qDay for up to 6 months Risk Reduction of NSAID-Associated Gastric Ulcer 20-40 mg PO qDay for up to 6 months NSAID-Induced Gastric Ulcer 20 mg PO qDay for 4-8 weeks Zollinger-Ellison Syndrome 80 mg PO divided q12hr (initial); adjust regimen to efficacy; up to 240 mg PO qDay, OR 120 mg PO q12hr administered to patients Elderly: No dosage adjustment needed. Hepatic Impairment Oral administration Mild to moderate (Child-Pugh A/B): No dosage adjustment required Severe (Child-Pugh C): Not to exceed 20 mg/day Child Dose: GERD Without Erosive Esophagitis Oral 12 years: 20-40 mg PO qDay for up to 8 weeks GERD With Erosive Esophagitis (Healing) 3.5-7.5 kg: 5 mg PO qDay for up to 6 weeks >7.5 kg: 10 mg PO qDay for up to 6 weeks 1-12 years 20 kg: 10-20 mg qDay for 8 weeks >12 years 20-40 mg PO qDay for 4-8 weeks Maintenance: 20 mg PO qDay up to 6 months Renal Dose: Renal impairment: No dosage adjustment needed.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Esomeprazole Magnesium Trihydrate is to be taken empty stomach.

If you miss a dose of Esomeprazole Magnesium Trihydrate, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Headache • Dizziness • Dryness in mouth • Nausea • Abdominal pain • Constipation • Flatulence • Diarrhea

[CONSULT YOUR DOCTOR] It is not known whether Esomeprazole Magnesium Trihydrate alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. It is a well-tolerated medicine and provides relief for a long time. Avoid eating late at night or before bedtime. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Long-term use of Esomeprazole Magnesium Trihydrate can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor. Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Esomeprazole is contraindicated in patients with known hypersensitivity to any component of the formulation or to substituted Benzimidazoles.

Increased risk of digoxin-induced cardiotoxic effects. Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. May increase serum concentration of tacrolimus, saquinavir, methotrexate. May interfere the elimination of drugs metabolised by CYP2C19 (e.g. diazepam). May decrease the bioavailability of ketoconazole, erlotinib and Fe salts. Potentially Fatal: May decrease serum concentration and pharmacological effects of rilpivirine, atazanavir and nelfinavir. May decrease the antiplatelet effects of clopidogrel.

[CAUTION] Caution is advised when consuming alcohol with Esomeprazole Magnesium Trihydrate. Please consult your doctor.

[CONSULT YOUR DOCTOR] Esomeprazole Magnesium Trihydrate may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Esomeprazole Magnesium Trihydrate is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Esomeprazole Magnesium Trihydrate is safe to use in patients with kidney disease. No dose adjustment of Esomeprazole Magnesium Trihydrate is recommended. However, inform your doctor if you have any kidney disease. [CAUTION] Esomeprazole Magnesium Trihydrate should be used with caution in patients with severe liver disease. Dose adjustment of Esomeprazole Magnesium Trihydrate may be needed. Please consult your doctor.

Heartburn Mental disorder Depression Frequent persistent heartburn Gastroesophageal reflux disease Irritable bowel syndrome Indigestion Back flow of acid from stomach Difficulty in swallowing Inflammation of esophagus Excess acid secretion by stomach Intestinal or stomach ulcers You need to be examined in clinic to reach a diagnosis and then appropriate medicine can be prescribed Having problem of acid reflux disease with throat infection and pain in right side of abdomen take avipattikar churan 1 spoon twice before meal, for throat infection do gargles with lyuke warm water and mixing tankan bhasma a littlein it,, My cough is not getting cured since 4-6 months. Tried some doctors, their medicines work for some time and the dry cough starts again. Though it happens occasionally, but i still cough It can be allergic cough or acid reflux disease. Can't give more opinion without seeing Having Amaryl 2 on a daily basis having vomiting tendencies Tab cap Nexpro 40 DSR twice dailyCheck blood sugar levels acid reflux, gastric, sugar stimulate acid reflux. CBC,ESR,LIPID PROFILE,URINE RE/CS, KFT, LFT, VIT D & B estimation,TAKE RABEKIND DSR once a day empty stomach FOR 3 week Suffering from acid reflux for last 7 years. Taking Nexpro RD 20 regularly since last 7 years. Though doctors are advising not to take nexpro for longtime. But I am helf less. Sometimes in spite of taking antacid, I feel pain in right or left chest due to acidity. To get rid off the pain I sometimes take nexpro fast 20 and it works. I check up health every year. I take cardace 5 for bp and lonazep md 0 25 regularly. My sugar fasting and lipid profile report is fine. Kindly inform acid reflux is curable or not and how. What are the long term effects of acid reflux. I have done endoscopy at least 3 times. Last was done before 3 years. May try antacids Good physical activity Avoid stress, smoking and alcohol Less Tea, coffee and milk More curd and butter milk Should meet a gastroenterologist Suffering from acid reflux disease due to which pain in throat and right side of lower abdomen Dear sir for the time being you can take Robinia 30, 04 drops in half cup water and Nixocid tab 2 tab thrice daily for a month, but as this case needs supervision, discussion and examination you need to visit a homeopath so that he can discuss your case in detail, get some investigations, do examination and guide you accordingly, Moderate Throat Pain in left side Moderate Ear pain. Acid reflux too often it may be due to acidity also you may have got some ulcer or infection in that region visit ent specialist near you for proper examination