Glucosamine Sulfate + Chondroitin

Introduction: Glucosamine Sulfate + Chondroitin is a combination supplement used for osteoarthritis of knee, hip, spine, hand and other locations. It is also beneficial in rheumatoid arthritis, sport injuries, migraine, skin problems, vascular complications and inflammatory bowel disease.

How it works: Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage. Chondroitin Sulfate provides substrate for proteoglycans and protects existing healthy cartilage by preventing the MMP enzyme that breaks down proteoglycans.

Important Information: This combination shows synergistic effect and is very much effective in severe cases of Osteoarthritis.

• Osteoarthritis - of knee, hip, spine, hand and other locations
• Rheumatoid arthritis
• Sport injuries
• Migraine
• Skin problems - psoriasis
• Vascular complications - atherosclerosis
• Inflammatory bowel disease

Stimulation of Cartilage formation

Glucosamine + Chondroitin

Glucosamine is a natural amino-sugar, produced by the body and found in certain foods. It is the most fundamental building block required for biosynthesis of glycosaminoglycans (GAGs) like Hyaluronic Acid, Keratan Sulfate, and Chondroitin Sulfate. Chondroitin Sulfate is a glycosaminoglycan found in connective tissue, especially in the articular cartilage. Combining Glucosamine with Chondroitin Sulfate shows synergistic effect. Data supports that this combination has been shown to be very much effective in severe cases of Osteoarthritis that treats both signs and symptoms of Osteoarthritis and modifies disease progression.

Glucosamine helps in cartilage formation and Chondroitin prevents cartilage degradation to improve joint health.

250/200 mg Tablet:

• 1 to 2 tablets, three times daily
• Dose may be adjusted according to response and body weight
• Doses can be tapered after 60 days

750/600 mg Tablet:

• 1 tablet two times daily or as directed by the physician

Dosage by Body Weight:

• Under 54 Kg: 1000 mg Glucosamine + 800 mg Chondroitin/day
• 54 Kg to 91 Kg: 1500 mg + 1200 mg/day
• Over 91 Kg: 2000 mg + 1600 mg/day

* Use as directed by the registered physician

Oral tablet. Can be taken with or without food. Take in the dose and duration as advised by your doctor.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and follow your regular schedule.

Side Effects:

• Safety studies with Glucosamine Sulfate & Chondroitin Sulfate show no demonstrable side effects
• Rarely occurring side effects (such as mild & reversible intestinal flatulence) are almost like placebo

Precautions:

• Avoid if allergic to shellfish or sulfur.
• Diabetics are advised to monitor blood glucose levels regularly when taking Glucosamine.
• Administration to patients with severe hepatic or renal insufficiency should be under appropriate medical supervision.
• Children should not be supplemented with Glucosamine and Chondroitin.

Contraindications:

• Allergy to shellfish or sulfur
• Proven hypersensitivity to Glucosamine or Chondroitin

Drug Interactions:

• No significant drug interactions with antibiotics, antidepressants, antihypertensives, nitrates, antiarrhythmics, anxiolytics, hypoglycemic agents
• Chondroitin may enhance the blood thinning effects of anticoagulants like Warfarin, Heparin

Food Interactions: No interaction found/established.

Use in Pregnancy: Women who are pregnant or who could become pregnant should not supplement with Glucosamine or Chondroitin. Not enough studies on use during pregnancy.

Use in Lactation: Should be taken with caution and medical advice during lactation.

Pediatric Use: Children should not be supplemented with Glucosamine and Chondroitin.

Geriatric Use: Use as per doctor's advice for elderly patients.

Renal Impairment: Administration to patients with severe renal insufficiency should be under appropriate medical supervision.

Hepatic Impairment: Administration to patients with severe hepatic insufficiency should be under appropriate medical supervision.

Overdose: Safety studies with Glucosamine Sulfate & Chondroitin Sulfate show no demonstrable side effects.

Storage: Store in a cool and dry place, protected from light.

Glucosamine Sulfate + Chondroitin Tablet