Generic
Hydroquinone + Octyldimethyl + Dioxybenzone + Oxybenzone
1 brands available in the market
At a glance
Hydroquinone + Octyldimethyl + Dioxybenzone + Oxybenzone cream is used for gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines and other unwanted areas of melanin hyperpigmentation.
Description
Hydroquinone + Octyldimethyl + Dioxybenzone + Oxybenzone cream is used for gradual bleaching of hyperpigmented skin conditions. Hydroquinone provides depigmenting action by suppressing melanocyte metabolic processes. Octyldimethyl P-aminobenzoate, Dioxybenzone and Oxybenzone act as sunscreens that block UVB and UVA rays and prevent repigmentation.
Indications
- Chloasma
- Melasma
- Freckles
- Senile lentigines
- Other melanin hyperpigmentation
- Hyperpigmentation caused by photosensitization associated with inflammation or use of certain cosmetics
Therapeutic class
Sunblock Preparation
Pharmacological class
Depigmenting Agent + Sunscreen (UVB/UVA)
Pharmacology
Hydroquinone is a topical depigmenting agent used in hyperpigmentation conditions by suppressing melanocyte metabolic processes. It also increases melanin excretion from melanocytes and prevents its production. Octyldimethyl P-aminobenzoate is used topically as a sunscreen. Dioxybenzone (benzophenone-8) blocks UVB and short-wave UVA rays. Oxybenzone is a broad-spectrum absorber that significantly augments UV-B protection.
Mechanism of action
Hydroquinone reduces melanin production; Sunscreen components block UV rays to prevent repigmentation.
Dosage
Adult Dose (Topical):
- Apply cream to affected area and rub in well twice daily or as directed by physician
- Most discolorations begin to lighten after 3-4 weeks (may take longer)
- After desired bleaching, use only as needed to maintain results
Child Dose: Safety and efficacy in children below 12 years have not been established
Administration
For external use only; clean and dry affected area before application; apply twice daily or as directed; wash hands after application; avoid contact with eyes and lips; do not apply to cut or abraded skin.
Missed dose
If you miss a dose, apply it as soon as possible; if it is almost time for your next dose, skip the missed dose.
Side effects
Side Effects:
- No systemic adverse reactions have been reported
- Occasional hypersensitivity (localized contact dermatitis) may occur; discontinue medication
Precautions & warnings
Precautions:
- Hydroquinone is a skin bleaching agent which may produce unwanted cosmetic effects if not used as directed
- Test for skin sensitivity before using (24 hours)
- Minor redness is not a contraindication, but itching, vesicle formation or excessive inflammatory response means further treatment is not advised
- If no bleaching or lightening effect after 2 months, discontinue medication
- Avoid contact with eyes and lips
- Do not apply to cut or abraded skin
Contraindications
Contraindications:
- Prior history of hypersensitivity or allergic reaction to hydroquinone or other ingredients
- Sunburn or depilatory usage
- Children under 12 years
Drug interactions
Peroxide: Concurrent use of peroxide may result in transient dark staining of skin areas due to oxidation of hydroquinone.
Food interactions
No food interaction found/established.
Use in pregnancy
Use in Pregnancy: It is not known whether hydroquinone can cause fetal harm or affect reproductive capacity; should be used in pregnant women only when clearly indicated.
Use in lactation
Use in Lactation: It is not known whether topical hydroquinone is absorbed or excreted in human milk; caution is advised.
Pediatric use
Safety and efficacy in children below 12 years have not been established.
Geriatric use
No specific data for elderly.
Renal / hepatic impairment
No specific data for renal or hepatic impairment.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Keep below 30°C temperature, away from light & moisture; keep out of reach of children.
Chemical structure
Hydroquinone + Octyldimethyl + Dioxybenzone + Oxybenzone