Generic
Hylan G-F 20
1 brands available in the market
At a glance
Hylan G-F 20 is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics.
Description
Hylan G-F 20 is an elastoviscous high molecular weight fluid containing hylan A and hylan B polymers produced from chicken combs. It is a derivative of hyaluronan (sodium hyaluronate) that is chemically crosslinked. It helps restore the shock-absorbing quality of synovial fluid in knee osteoarthritis patients, reducing pain and enabling a more active lifestyle.
Indications
- Pain in osteoarthritis (OA) of the knee (in patients who have failed to respond adequately to conservative nonpharmacologic therapy and simple analgesics)
Pharmacological class
Viscosupplement (Hyaluronic Acid Derivative)
Pharmacology
Hylan G-F 20 is an elastoviscous fluid that is a chemically crosslinked derivative of hyaluronan (sodium hyaluronate) produced from chicken combs. In patients with knee osteoarthritis, it helps restore the shock-absorbing quality of synovial fluid, reducing pain and enabling a more active lifestyle.
Mechanism of action
Restores the shock-absorbing quality of synovial fluid in the knee and acts as a lubricant to reduce pain.
Dosage
Adult Dose (Intra-articular):
- One injection once a week (one week apart) for a total of three injections
- Remove synovial fluid or effusion before each injection
- Use an 18- to 22-gauge needle
- Do not use the same syringe for removing fluid and for injecting; same needle can be used
Pediatric Dose: Safety and effectiveness have not been established (pediatric patients ≤21 years)
Administration
Administered only under doctor supervision as intra-articular injection; strict aseptic technique must be followed; remove synovial fluid or effusion before each injection; twist tip cap before pulling off; secure needle tightly while holding luer hub.
Missed dose
If you miss a dose, please consult your doctor.
Drug interactions
No significant drug interactions known.
Food interactions
No food interaction found/established.
Contraindications
Contraindications:
- Known hypersensitivity to hyaluronan (sodium hyaluronate) preparations
- Knee joint infections
- Skin diseases or infections in the area of the injection site
Side effects
Most Commonly Reported Adverse Events:
- Pain in the injected knee
- Swelling in the injected knee
- Joint effusion
Use in pregnancy
Use in Pregnancy: Safety and effectiveness have not been established in pregnant women.
Use in lactation
Use in Lactation: It is not known if Hylan G-F 20 is excreted in human milk; safety and effectiveness have not been established in lactating women.
Precautions & warnings
Precautions:
- Effectiveness of less than three injections has not been established
- Safety and effectiveness in locations other than the knee and for conditions other than osteoarthritis have not been established
- Safety and effectiveness with other intra-articular injectables not established
- Caution in patients allergic to avian proteins, feathers, and egg products
- Safety and effectiveness in severely inflamed knee joints not established
- Caution with evidence of lymphatic or venous stasis in the leg
- Do not use disinfectants containing quaternary ammonium salts for skin preparation
Pediatric use
Safety and effectiveness have not been established in pediatric patients (≤21 years).
Geriatric use
No specific data for elderly.
Renal / hepatic impairment
No specific data for renal or hepatic impairment.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Therapeutic class
Drugs for Osteoarthritis
Storage conditions
Store in original packaging (protected from light) at room temperature below 86°F (30°C); DO NOT FREEZE; do not use if package is opened or damaged.
Chemical structure
Hylan G-F 20