Generic
Hyoscine Butyl Bromide
41 brands available in the market
At a glance
Hyoscine Butyl Bromide is used for the relief of pain due to smooth muscle spasm, especially cramps in the stomach, intestine, bladder and ureter.
Description
Hyoscine Butyl Bromide is an anticholinergic medication that relaxes the muscles in the stomach and intestine. It stops sudden muscle contractions (spasms), relieving cramps, pain, bloating and discomfort. It is indicated for visceral spasms in the gastrointestinal or genitourinary tract, spasmodic dysmenorrhea (painful periods), and acute renal or biliary colic.
Indications
- Visceral spasms in the gastrointestinal tract
- Visceral spasms in the genitourinary tract
- Spasmodic dysmenorrhea (painful periods)
- Acute renal (kidney) colic
- Acute biliary (gallbladder) colic
- Relief of spasms during diagnostic and radiological procedures
Therapeutic class
Anticholinergics (antimuscarinics)/ Anti-spasmodics
Pharmacological class
Antimuscarinic Agent
Pharmacology
Hyoscine Butylbromide is an anticholinergic drug with an antispasmodic action on the smooth muscles of various organs. It competitively blocks muscarinic receptors and has central and peripheral actions. It relaxes smooth muscle and reduces gastric and intestinal motility.
Mechanism of action
Relaxes smooth muscle by blocking muscarinic receptors and relieves spasms in the gastrointestinal and genitourinary tract.
Dosage
Adult Dose (Oral):
- Gastrointestinal & Genitourinary spasm: 20 mg 4 times daily
- Spasmodic dysmenorrhea: Start at least 2 days before menstruation and continue up to 3 days after period starts
Adult Dose (Parenteral):
- Gastrointestinal & Genitourinary spasm: 20 mg IM/IV, repeat after 30 min if needed; Max: 100 mg daily
Child Dose (6-12 years, Oral):
- Gastrointestinal & Genitourinary spasm: 10 mg 3 times daily
Administration
Your doctor or nurse will give you this medicine; do not self administer. Oral tablets may be taken with or without food. Injection is given IM or IV. During endoscopy, more frequent doses may be needed.
Missed dose
If you miss a dose, take it as soon as possible; if it is almost time for your next dose, skip the missed dose and go back to regular schedule; do not double the dose.
Side effects
Common Side Effects:
- Blurred vision
- Increased heart rate
- Dryness in mouth
- Diarrhea
- Dilatation of pupil
Others: Dry skin, flushing, bradycardia followed by tachycardia and arrhythmia, fatigue, vomiting, dizziness, staggering
Precautions & warnings
Precautions:
- Hyoscine Butyl Bromide may decrease alertness and affect vision; do not drive if these symptoms occur
- Avoid alcohol (may increase drowsiness)
- Inform doctor if you have heart problems, thyroid problems, fever, constipation or difficulty urinating
- Caution in prostatic enlargement (BPH); caution in elderly patients
- Concurrent use with other anticholinergic drugs may enhance effect
Contraindications
Contraindications:
- Narrow-angle glaucoma
- Acute haemorrhage
- Paralytic ileus
- Tachycardia due to cardiac insufficiency
- Myasthenia gravis
- Pyloric stenosis
Drug interactions
Drug Interactions:
- Additive sedative effects with alcohol or other CNS depressants
- Effect potentiated by other anticholinergic drugs and TCAs
- Reduced effects with acetylcholinesterase inhibitors (donepezil, galantamine, rivastigmine, tacrine)
Food interactions
Food Interactions: Hyoscine Butyl Bromide may cause excessive drowsiness with alcohol.
Use in pregnancy
Use in Pregnancy: Caution during first trimester; animal studies have shown harmful effects; doctor will weigh benefits and risks.
Use in lactation
Use in Lactation: Safe during breastfeeding; does not pass into breastmilk in significant amount; single dose unlikely to interfere with breastfeeding, but milk secretion may decrease during long-term use.
Pediatric use
Pediatric Use: 6-12 years: 10 mg 3 times daily; no data for children under 6 years.
Geriatric use
Geriatric Use: Caution due to prostatic enlargement; dose adjustment may be needed.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Caution in liver disease; dose adjustment may be needed.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Do not use after expiration date; keep out of reach of children; dispense only by prescription of registered physician.
Chemical structure
Hyoscine Butyl Bromide