Generic
Jogaraj Guggulu
3 brands available in the market
At a glance
Jogaraj Guggulu is used for rheumatoid arthritis, osteoarthritis, neuralgias, myalgias, spondylitis, backaches, joint pain, and joint stiffness.
Description
Jogaraj Guggulu is a proper preparation of different herbs, therapeutically effective in rheumatoid disorder. It contains Commiphora mukul (Guggulu) 250 mg extract with Plumbago zeylanicum, Piper longum, Trachyspermum ammi, Nigella sativa, Cuminum cyminum, Cedrus deodara, Apium graveolans, Elettaria cardamomum, Saussurea lappa, Tribulus terrestris, Terminalia chebula, Emblica officinalis, Terminalia belerica and other ingredients. Due to the presence of guggulsterone E & Z, it has analgesic & anti-inflammatory properties.
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Neuralgias
- Myalgias (muscle pain)
- Spondylitis
- Backaches
- Joint pain/Arthralgia
- Joint stiffness
Therapeutic class
Herbal and Nutraceuticals
Pharmacological class
Anti-inflammatory/Analgesic Herbal Supplement
Pharmacology
Guggulsterone E & Z from Commiphora mukul are responsible for anti-inflammatory activity. Piperine from Piper longum has anti-inflammatory activity. Gallic acid from Terminalia chebula & Terminalia belerica and ascorbic acid from Emblica officinalis are responsible for antioxidant activity. Flavonoids from Plumbago zeylanicum inhibit prostaglandin synthesis to reduce pain.
Mechanism of action
Guggulsterone inhibits NF-kappa-B activation for anti-inflammatory effect; Flavonoids inhibit prostaglandin synthesis for pain relief; Thymoquinone inhibits nociceptive system to reduce pain.
Dosage
Adult Dose (Oral):
- 1 capsule 2-3 times a day after meals
- As advised by the physician
Child Dose (Oral):
- 1 capsule 1/2 times daily
Administration
Administered only orally; take 1 capsule 2-3 times daily after meals; as advised by the physician.
Missed dose
If you miss a dose, take it as soon as possible; if it is almost time for your next dose, skip the missed dose and go back to regular schedule; do not double the dose.
Side effects
Side Effects:
- Stomach upset
- Headache
- Nausea
- Vomiting
- Belching and hiccups
- Diarrhea
- Allergic reactions
Precautions & warnings
Precautions:
- Guggulu might act like estrogen in the body; do not use if you have any condition that might be made worse by exposure to estrogen
- Caution in hyperthyroidism, diarrhea, during use of antihypertensive, antifungal & lipid lowering medication
- Caution in kidney disease
Contraindications
Contraindications:
- Known allergy to plants or guggulu
- Pregnancy and lactation
Drug interactions
Drug Interactions:
- May increase side effects of estrogen
- May decrease effectiveness of diltiazem
- May decrease effectiveness of atorvastatin, ketoconazole, itraconazole, fexofenadine
- May increase effects & side effects of thyroid hormone
Food interactions
No food interaction found/established.
Use in pregnancy
Use in Pregnancy: Jogaraj guggulu should not be used during pregnancy or lactation.
Use in lactation
Use in Lactation: Jogaraj guggulu should not be used during pregnancy or lactation.
Pediatric use
Child dose: 1 capsule 1/2 times daily.
Geriatric use
Safe for elderly; no special precautions needed.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed; consult your doctor.
Hepatic Impairment: No specific data; consult your doctor.
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Keep in a cool, dry place & away from direct sunlight; keep out of children's reach.
Chemical structure
Jogaraj Guggulu