Generic
Ketoprofen
36 brands available in the market
At a glance
Ketoprofen is a pain relieving and anti-inflammatory medicine used for various pain conditions of muscles, bones and joints. It is effective for soft tissue injuries, muscle strains and sprains.
Description
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation by inhibiting prostaglandin synthesis. It provides analgesic action by blocking prostaglandin synthesis peripherally and centrally. It also stabilizes lysosomal membranes and inhibits leukotriene synthesis. The drug is rapidly and almost completely absorbed from the GI tract and is approximately 99% bound to plasma protein.
Indications
- Rheumatoid arthritis
- Osteoarthritis (degenerative joint diseases)
- Musculoskeletal disorders such as tendinitis, sprain
- Dental pain, headache and primary dysmenorrhea
Therapeutic class
NSAIDs
Pharmacological class
Non-steroidal Anti-inflammatory Drug
Pharmacology
Ketoprofen is an NSAID that inhibits prostaglandin synthesis. It stabilizes lysosomal membranes, inhibits leukotriene synthesis, and exhibits antibradykinin activity.
Mechanism of action
Ketoprofen reduces pain and inflammation by inhibiting prostaglandin synthesis. It suppresses prostaglandin synthesis in the CNS to produce antipyretic effects.
Dosage
Adult Dose (Anti-inflammatory):
- Starting dose: 150-300 mg daily in 3 divided doses
- Maintenance dose: Usually 100-200 mg daily
- Maximum daily dose: 300 mg
Pain and Dysmenorrhea Management:
- 25-50 mg every 6-8 hours as needed
- Maximum daily dose: 300 mg
Administration
- Oral forms should be taken with fluids, preferably with food
- For external use only (topical forms)
Missed dose
If you miss a dose, take it as soon as you remember; skip if it's almost time for next dose.
Side effects
Common Side Effects:
- Dyspepsia
- Nausea
- Abdominal pain
- Vomiting
Uncommon Side Effects:
- Constipation, diarrhea, flatulence, gastritis
- Headache, dizziness, somnolence
Precautions & warnings
- Use with caution in patients with history of peptic ulcer or bleeding
- Caution in patients with heart failure, cirrhosis or nephrosis
- Caution in patients with hypertension or heart problems
- Elderly patients should start with reduced dosage
- Regular monitoring required for liver or kidney problems
- Not recommended for pregnant women or those trying to conceive
Contraindications
- History of hypersensitivity to ketoprofen or other NSAIDs
- Active or history of peptic ulcer
- History of gastrointestinal bleeding or perforation
- Severe heart failure
- Severe hepatic or renal insufficiency
- Third trimester of pregnancy
Drug interactions
- Increased risk of GI ulceration and bleeding with other NSAIDs or salicylates
- Increased risk of bleeding with anticoagulants
- Risk of elevated lithium plasma levels with lithium
- Increased risk of hematologic toxicity with methotrexate
- May impair renal function with ACE inhibitors or diuretics
Food interactions
No food interactions found
Use in pregnancy
First and Second Trimester: Should be avoided; safety not evaluated.
Third Trimester: Contraindicated.
Use in lactation
Not recommended during breastfeeding.
Pediatric use
Safety and efficacy not established in children.
Geriatric use
Elderly patients should start with reduced dosage and maintain at minimal effective dose.
Renal / hepatic impairment
- Hepatic impairment: Monitor carefully and maintain at minimal effective daily dose.
- Renal impairment: Start with reduced dosage and maintain at minimal effective dose.
Overdose effects
Overdose symptoms include lethargy, drowsiness, nausea, vomiting and epigastric pain. No specific antidote; symptomatic treatment is recommended.
Storage conditions
Store below 30°C, protected from light; keep out of reach of children.
Chemical structure
Ketoprofen