Generic
Lansoprazole
25 brands available in the market
At a glance
Lansoprazole is a proton pump inhibitor (PPI) that reduces stomach acid production. It is used for acid-related diseases such as heartburn, acid reflux, peptic ulcer, and Zollinger-Ellison syndrome.
Description
Lansoprazole is a substituted benzimidazole compound that blocks the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cells. It inhibits both basal and stimulated acid secretion. The medicine should be taken before meals and long-term use may lead to bone loss and magnesium deficiency.
Indications
- Gastroesophageal reflux disease (GERD)
- Duodenal ulcer and benign gastric ulcer
- Acid-related dyspepsia
- Zollinger-Ellison syndrome
- NSAID-induced ulcer prevention
- H. pylori eradication (in combination with antibiotics)
Therapeutic class
Proton Pump Inhibitor (PPI)
Pharmacological class
Benzimidazole Derivative
Pharmacology
Lansoprazole is a PPI that blocks the final step of acid secretion by inhibiting H+/K+ ATPase enzyme system in gastric parietal cells.
Mechanism of action
Reduces stomach acid production by blocking the final step of acid secretion.
Dosage
Adult Dose (Oral):
- GERD: 15-30 mg once daily in the morning for 4-8 weeks
- Duodenal ulcer: 30 mg once daily in the morning for 4 weeks; Maintenance: 15 mg/day
- Gastric ulcer: 30 mg once daily for 8 weeks
- Zollinger-Ellison: 60 mg once daily; adjust as needed (>120 mg/day in 2 divided doses)
- NSAID-induced ulcer prevention: 15-30 mg once daily
- H. pylori eradication: 30 mg twice daily + clarithromycin + amoxicillin/metronidazole for 1 week
Children (GERD/Erosive Esophagitis): 1-11 years: 15-30 mg once daily for up to 12 weeks; 12-17 years: 15-30 mg once daily for up to 8 weeks
Administration
- Dissolve in a glass of water and take on an empty stomach (1 hour before a meal)
- Preferably take in the morning
- Antacids and sucralfate may reduce bioavailability
Missed dose
If you miss a dose, take it as soon as possible. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Headache
- Dizziness
- Fatigue
- Diarrhea
- Constipation
- Abdominal pain
- Nausea
- Vomiting
- Flatulence
- Dry mouth
- Skin rash
Precautions & warnings
- Rule out gastric malignancy before treatment
- Long-term use may lead to bone loss and magnesium deficiency
- Take calcium and magnesium supplements
- Dose adjustment needed in severe liver disease (max 30 mg/day)
- Inform your doctor if you experience watery diarrhea, fever, or abdominal pain
Contraindications
- Hypersensitivity to Lansoprazole or its components
Drug interactions
- Increased risk of hypomagnesemia with diuretics and digoxin
- Decreased bioavailability of itraconazole and ketoconazole
- May decrease serum levels of rilpivirine and atazanavir (potentially fatal)
- Reduced bioavailability with antacids and sucralfate
Food interactions
Caution is advised when consuming alcohol with Lansoprazole; consult your doctor.
Use in pregnancy
Use in Pregnancy: Lansoprazole is generally considered safe during pregnancy (FDA Category B). Animal studies have shown low or no adverse effects to the developing baby.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Lansoprazole is probably safe during breastfeeding. Limited human data suggests no significant risk to the baby.
Pediatric use
Pediatric doses are established (age and weight-based).
Geriatric use
No special dose adjustment needed in elderly.
Renal / hepatic impairment
Renal Impairment: Safe in kidney disease; no dose adjustment needed.
Hepatic Impairment: Use with caution in severe liver disease; dose adjustment may be needed (max 30 mg/day).
Overdose effects
No specific overdose information available; excessive doses may increase side effects.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.
Chemical structure
Lansoprazole