Leuprolide acetate

Leuprolide acetate is used in the treatment of prostate cancer. It is also used to treat endometriosis (endometrium of the uterus grows excessively and causes symptoms like pain, heavy or irregular periods), uterine fibroids and central precocious puberty (very early puberty). Leuprolide acetate is given as an injection under the skin by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Decreased libido, increased sweating, fatigue, muscle weakness, and hot flashes are some very common side effects of this medicine. The long-term use of medicine may cause weakened bones and reduction in bone mineral density. You are advised to take vitamin D and calcium supplements while taking this medicine. It might cause menstrual periods to stop for a period of 7- 12 weeks, inform your doctor if menstrual bleeding continues even during the treatment. Before taking this medicine, inform your doctor if you have a history of drinking alcohol, smoker, and osteoporosis. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Leuprolide acetate is a hormone similar to the one produced by a hypothalmus gland in the brain. It works by decreasing the blood levels of testosterone in males.

• Prostate cancer • Endometriosis • Uterine fibroids • Precocious puberty (premature puberty)

Leuprorelin is a gonadotropin-releasing hormone (GnRH) analogue. Following an initial stimulation of gonadotrophins, continuous admin of Leuprorelin leads to down regulation of GnRH receptors and subsequently reduces pituitary gonadotrophin secretion. Reduced gonadotrophin levels lead to inhibition of sex hormone (testosterone and oestrogen) production. Within 2-4 wk after treatment initiation, testosterone levels in male may be reduced to below castrate threshold.

Adult Dose: Advanced Prostate Cancer Recommended Dose: 1 mg (0.2 mL) administered as a single daily SC injection. Endometriosis 3.75 mg IM monthly for up to 6 months or 11.25 mg IM every 3 months for 2 doses (6 months total) Recommended duration of treatment is 6 months; may treat again for additional 6 months, but with concomitant administration of norethindrone Uterine Leiomyomata (Fibroids) 3.75 mg IM monthly for up to 3 months or 11.25 mg IM once Use concomitant iron treatment Child Dose: Central Precocious Puberty Indicated when signs of sexual maturity begin to develop in girls <8 years old and boys <9 years old; may be discontinued at appropriate age of onset of puberty (eg, 11 years in females and 12 years in males), at physician's discretion 50 mcg/kg/day SC; may be titrated upward by 10 mcg/kg/day if downregulation not achieved <2 years old: Safety and efficacy not established

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Leuprolide acetate, please consult your doctor.

Common: • Decreased libido • Testicular atrophy • Increased sweating • Fatigue • Muscle weakness • Erectile dysfunction • Bone pain • Injection site reaction

[UNSAFE] Leuprolide acetate may cause side effects which could affect your ability to drive. Do not drive or operate machinery if you experience drowsiness, dizziness or visual disturbances whilst being treated with Leuprolide acetate. Leuprolide acetate helps in the treatment of locally advanced or metastatic prostate cancer. It may also be used to treat endometriosis and uterine fibroids. It is given as an injection either under the skin or into a muscle. It may cause dizziness and visual disturbances. Don't drive or do anything that requires mental focus until you know how it affects you. It will cause menstrual periods to stop. Periods will resume 7-12 weeks after the final injection. Consult your doctor if you experience menstrual bleed despite treatment. Use non-hormonal methods of contraception such as condoms to prevent pregnancy during treatment, as this medicine may be harmful to a developing baby. Long term treatment may lead to bone loss and a higher risk of bone fractures, especially if you are a heavy drinker, a smoker, or have a family history of osteoporosis.

Pregnancy, lactation; hypersensitivity to GnRH, GnRH agonist analogs or product excipients; undiagnosed abnormal vaginal bleeding.

[CAUTION] Caution is advised when consuming alcohol with Leuprolide acetate. Please consult your doctor.

[UNSAFE] Leuprolide acetate is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[CONSULT YOUR DOCTOR] Information regarding the use of Leuprolide acetate during breastfeeding is not available. Please consult your doctor.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Leuprolide acetate in patients with kidney disease. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Leuprolide acetate in patients with liver disease. Please consult your doctor.

He has prostate cancer patient under gone surgery and biopsy report confirm it. He was taking lupride injection quarterly. but this injection is not available now. his PSA is now 14.3. .please suggest us. Will forward you number, you will get it from himcall him for Injection In which age does the girls have hairs in their undearms During Puberty and the age range varies Size of penish does not increase Size of penis will not increase after puberty I am suffering with uterine fibroids & get it treated. Treatment would depend on size and site of the fibroids, age and parity and also on symptoms. A detailed evaluation would be required. I suggest you visit a gynaecologist in your area or you could visit me at my clinic in Gurgaon. How to make increase in height She attained her puberty at the age of nine. After that her growth is stunned. for the last three years her height is not increased.pls suggest any growth stimulators Once puberty is attained there is not much increase in height. and height is genetically determined He always thinks about sex. How can he avoid that thinking whats the way to avoid that thinking plz give me a better solution for this problem because he is just 14 year old boy Its normal for all boys especially at this puberty age . Focus on your studies and career. Her bone age is 10 yrs 9 months . Can I give decapeptyl injection to stop puberty . She is very short Worried about bone density There are many underlying causes of patient?s symptoms. Different cause needs different treatment. Specific treatment cannot be given unless we establish exact underlying cause. Final and perfect diagnosis cannot be done without doing clinical examination of patient. Please consult me or any other Paediatrician. will take detail history and will examine patient in detail. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment. How to get treated for uterine fibroids Is fibroid reason for infertility Maybe it can cause but site of fibroid and the size is important