Generic
Magnesium Sulphate inj
3 brands available in the market
At a glance
Magnesium Sulphate injection is used for decreased magnesium levels in blood and for controlling seizures in pregnant women with high blood pressure. It widens blood vessels in the brain and improves blood supply to nerve cells.
Description
Magnesium sulfate decreases levels of acetylcholine in motor nerve terminals and acts on the myocardium by decreasing the rate of SA node impulse formation and prolonging conduction time. It corrects magnesium deficiency and controls seizures in eclampsia.
Indications
- Seizures in pregnant women with high blood pressure (eclampsia/pre-eclampsia)
- Decreased magnesium levels in blood (hypomagnesemia)
- Torsades de pointes
- Barium poisoning
- Cerebral edema
Therapeutic class
Specific Mineral Preparations
Pharmacological class
Electrolyte / Anticonvulsant
Pharmacology
Magnesium sulfate decreases acetylcholine levels in motor nerve terminals and acts on the myocardium by decreasing SA node impulse formation and prolonging conduction time.
Mechanism of action
Widens blood vessels in the brain to improve blood supply to nerve cells and controls seizures.
Dosage
Hypomagnesemia (IV): 1-2 g over 5-60 mins, then 0.5-1 g/hr
Torsades de pointes: 1-2 g over 5-60 mins
Eclampsia: Loading: 4-5 g over 10-15 mins, then 1 g/hr IV OR IM 4-5 g every 4 hours; max 30-40 g/24 hr
IM (Mild deficiency): 1 g 6 hourly for 4 doses
Administration
- Administered by doctor or nurse only; do not self-administer
- Monitor blood pressure, respiration, and patellar reflex during injection
Missed dose
If you miss a dose, please consult your doctor.
Side effects
Common Side Effects:
- Injection site reactions (pain, swelling, redness)
- Nausea, vomiting
- Flushing, thirst
- Hypotension, drowsiness, confusion
Precautions & warnings
- Caution in patients with bleeding disorders, heart block, kidney problems, or breathing problems
- Caution if taking nervous system, heart, or hypertension medications
- Monitor serum-magnesium concentrations
- Caution in pregnancy
Contraindications
- Heart block
- Severe renal impairment
- Myocardial damage
Drug interactions
- Enhances neuromuscular blockers
- Enhances digitalis glycosides
Food interactions
Caution with alcohol; consult your doctor.
Use in pregnancy
Use in Pregnancy: Magnesium Sulphate injection is unsafe during pregnancy (Category D); definite evidence of risk to the fetus. Used under supervision in eclampsia.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Magnesium Sulphate injection is safe during breastfeeding; does not pass into breastmilk in significant amounts.
Pediatric use
Safety and efficacy not established in children; use as directed by physician.
Geriatric use
Caution needed in elderly.
Renal / hepatic impairment
Renal Impairment: Caution in kidney disease; dose adjustment may be needed.
Hepatic Impairment: Probably safe in liver disease; dose adjustment may not be needed.
Overdose effects
Overdose causes magnesium toxicity - breathing difficulty, loss of reflexes; treat with calcium gluconate and supportive care.
Storage conditions
Store in a cool and dry place; keep out of reach of children.
Chemical structure
Magnesium Sulphate Injection